Efficacy and safety of tacrolimus compared with ciclosporin-A in renal transplantation: 7-year observational results.

The European Tacrolimus versus Ciclosporin-A Microemulsion (CsA-ME) Renal Transplantation Study demonstrated that tacrolimus decreased acute rejection rates at 6 months. Primary endpoints of this investigator-initiated, observational 7-year follow-up study were acute rejection rates, patient and graft survival rates, and a composite endpoint (BPAR, graft loss, and patient death). We analyzed data from the original intent-to-treat population (n = 557; 286 tacrolimus, 271 CsA-ME). A total of 237 tacrolimus and 208 CsA-ME patients provided data. At 7 years, Kaplan-Meier estimated rates of patients free from BPAR were 77.1% in the tacrolimus arm and 59.9% in the CsA-ME arm, graft survival rates amounted to 82.6% and 80.6%, and patient survival rates to 89.9% and 88.1%. Estimated combined endpoint-free survival rates were 60.2% in the tacrolimus arm and 47.0% in the CsA-ME arm (P = <0.0001). A higher number of patients from the CsA-ME arm crossed over to tacrolimus during 7 year follow-up: 19.7% vs. 7.9% (P = <0.002). More patients in the tacrolimus group stopped steroids and received immunosuppressive monotherapy. Significantly, more CsA-ME patients received lipid-lowering medication and experienced cosmetic and cardiovascular adverse events. Tacrolimus-treated renal transplant recipients had significantly higher combined endpoint-free survival rates mainly driven by lower acute rejection rates despite less immunosuppressive medication at 7 years.

Krämer BK ，Montagnino G ，Krüger B ，Margreiter R ，Olbricht CJ ，Marcen R ，Sester U ，Kunzendorf U ，Dietl KH ，Rigotti P ，Ronco C ，Hörsch S ，Banas B ，Mühlbacher F ，Arias M ，European Tacrolimus versus Ciclosporin Microemulsion Renal Transplantation Study Group ... -  《-》

Efficacy and safety of tacrolimus compared with cyclosporin A microemulsion in renal transplantation: 2 year follow-up results.

Krämer BK ，Montagnino G ，Del Castillo D ，Margreiter R ，Sperschneider H ，Olbricht CJ ，Krüger B ，Ortuño J ，Köhler H ，Kunzendorf U ，Stummvoll HK ，Tabernero JM ，Mühlbacher F ，Rivero M ，Arias M ，European Tacrolimus vs Cyclosporin Microemulsion Renal Transplantation Study Group ... -  《NEPHROLOGY DIALYSIS TRANSPLANTATION》

Efficacy and safety of tacrolimus compared with ciclosporin A in renal transplantation: three-year observational results.

Krämer BK ，Del Castillo D ，Margreiter R ，Sperschneider H ，Olbricht CJ ，Ortuño J ，Sester U ，Kunzendorf U ，Dietl KH ，Bonomini V ，Rigotti P ，Ronco C ，Tabernero JM ，Rivero M ，Banas B ，Mühlbacher F ，Arias M ，Montagnino G ，European Tacrolimus versus Ciclosporin Microemulsion Renal Transplantation Study Group ... -  《-》

A randomized trial with steroids and antithymocyte globulins comparing cyclosporine/azathioprine versus tacrolimus/mycophenolate mofetil (CATM2) in renal transplantation.

Vacher-Coponat H ，Moal V ，Indreies M ，Purgus R ，Loundou A ，Burtey S ，Brunet P ，Moussi-Frances J ，Daniel L ，Dussol B ，Berland Y ... -  《-》

Results of lis2t, a multicenter, randomized study comparing cyclosporine microemulsion with C2 monitoring and tacrolimus with C0 monitoring in de novo liver transplantation.

Levy G ，Villamil F ，Samuel D ，Sanjuan F ，Grazi GL ，Wu Y ，Marotta P ，Boillot O ，Muehlbacher F ，Klintmalm G ，LIS2T Study Group ... -  《TRANSPLANTATION》