Evaluation of 4DryField® PH as Adhesion Prevention Barrier Tested in an Optimized Adhesion Model in Rats.

Adhesions due to pelvic/abdominal surgery are a common serious pathology possibly entailing severe complications. This study investigates the adhesion prevention capability of the novel starch-based agent 4DryField® PH, which together with saline solution forms a barrier gel. Herein, an optimized adhesion model (OPAM) inducing severe adhesions/agglutinations with high reproducibility was used. In 19 Lewis rats, a 1 × 2 cm abdominal wall defect was created, the peritoneum of the neighboring cecum was abraded, and both injured areas were approximated by suture. Rats were randomized to control (n = 10) or 4DryField PH treatment (n = 9) groups. Another 8 rats had sham surgery for safety assessment of 4DryField PH. At day 7, the quantity and quality of adhesions were assessed macro-/microscopically and evaluated statistically. 4DryField PH treatment significantly reduced the incidence and severity of adhesions as verified by significantly improved adhesion scorings (0.4 vs. 4.5; 1.1 vs. 9). Histology revealed reconstitution of the cecum and abdominal wall including regeneration of the visceral/parietal peritoneum. In sham-operated rats, 4DryField PH did not induce adhesion formation. 4DryField PH gel was highly effective in preventing adhesions. Histologically, the injured cecum and abdominal wall regenerated well in the presence of 4DryField PH. Considering the severity of OPAM trauma, the potential of 4DryField PH to prevent adhesions can be rated excellent.

Poehnert D ，Abbas M ，Kreipe HH ，Klempnauer J ，Winny M ... -  《-》

High reproducibility of adhesion formation in rat with meso-stitch approximation of injured cecum and abdominal wall.

Poehnert D ，Abbas M ，Kreipe HH ，Klempnauer J ，Winny M ... -  《International Journal of Medical Sciences》

Evaluation of the Effectiveness of Peritoneal Adhesion Prevention Devices in a Rat Model.

Poehnert D ，Grethe L ，Maegel L ，Jonigk D ，Lippmann T ，Kaltenborn A ，Schrem H ，Klempnauer J ，Winny M ... -  《International Journal of Medical Sciences》

Treatment of de-peritonealized intestine with 4DryField(®) PH prevents adhesions between non-resorbable intra-peritoneal hernia mesh and bowel.

Winny M ，Maegel L ，Grethe LV ，Jonigk D ，Borchert P ，Kaltenborn A ，Schrem H ，Klempnauer J ，Poehnert D ... -  《American Journal of Translational Research》

Comparison of adhesion prevention capabilities of the modified starch powder-based medical devices 4DryField(®) PH, HaemoCer™ PLUS and StarSil(®) in the Optimized Peritoneal Adhesion Model.

Poehnert D ，Neubert L ，Winny M 《International Journal of Medical Sciences》