The prognostic significance of CXCL16 and its receptor C-X-C chemokine receptor 6 in prostate cancer.

The chemokine CXCL16 and its receptor, C-X-C chemokine receptor (CXCR6), affect tumor progression through different pathways, including leukocyte recruitment and function, cellular senescence, tumor cell proliferation, survival, invasion, and metastasis. We examined how the expression of CXCL16/CXCR6 in prostate cancer (PC) was related to clinicopathological features and activation of inflammatory cells. Tissue microarrays from 535 patients were constructed from tumor epithelial and tumor stromal areas of primary PC. Immunohistochemistry was used to evaluate the expression of CXCL16/CXCR6, CD3(+) T cells (CD4(+), CD8(+)), and CD20(+) B cells. Survival analyses were used to evaluate their prognostic impact. Expression of CXCL16 in PC cell lines (DU145 and PC3) and the effect on proliferation and migration were examined. High expression levels of CXCL16 [hazard ratio (HR), 2.52; 95% CI, 1.12-5.68; P = 0.026] and CXCR6 (HR, 2.29; 95% CI, 1.10-4.82; P = 0.028) were each independent predictors for clinical failure. High co-expression of CXCL16 and CXCR6 (HR, 5.1; 95% CI, 1-15.9; P = 0.05) was associated with negative prognostic factors, such as Gleason grade 4 + 3, Gleason score ≥7, vascular infiltration, and positive surgical margins. As a conclusion, high protein expression of CXCL16 and high protein co-expression of CXCL16/CXCR6 in PC were independent predictors for a worse clinical outcome.

Richardsen E ，Ness N ，Melbø-Jørgensen C ，Johannesen C ，Grindstad T ，Nordbakken C ，Al-Saad S ，Andersen S ，Dønnem T ，Nordby Y ，Bremnes RM ，Busund LT ... -  《-》

Clinical significance of CXCL16/CXCR6 expression in patients with prostate cancer.

Ha HK ，Lee W ，Park HJ ，Lee SD ，Lee JZ ，Chung MK ... -  《-》

[Role of CXCL16/CXCR6 axis in the metastasis of human prostate cancer].

Zhou WH ，Hu WD ，Wu ZQ ，Zheng XM ，Wang BC ... -  《-》

CXCL16 functions as a novel chemotactic factor for prostate cancer cells in vitro.

Lu Y ，Wang J ，Xu Y ，Koch AE ，Cai Z ，Chen X ，Galson DL ，Taichman RS ，Zhang J ... -  《MOLECULAR CANCER RESEARCH》

CXCR6-CXCL16 axis promotes prostate cancer by mediating cytoskeleton rearrangement via Ezrin activation and αvβ3 integrin clustering.

Singh R ，Kapur N ，Mir H ，Singh N ，Lillard JW Jr ，Singh S ... -  《Oncotarget》