JMJD3 as an epigenetic regulator in development and disease.

Gene expression is epigenetically regulated through DNA methylation and covalent chromatin modifications, such as acetylation, phosphorylation, ubiquitination, sumoylation, and methylation of histones. Histone methylation state is dynamically regulated by different groups of histone methyltransferases and demethylases. The trimethylation of histone 3 (H3K4) at lysine 4 is usually associated with the activation of gene expression, whereas trimethylation of histone 3 at lysine 27 (H3K27) is associated with the repression of gene expression. The polycomb repressive complex contains the H3K27 methyltransferase Ezh2 and controls dimethylation and trimethylation of H3K27 (H3K27me2/3). The Jumonji domain containing-3 (Jmjd3, KDM6B) and ubiquitously transcribed X-chromosome tetratricopeptide repeat protein (UTX, KDM6A) have been identified as H3K27 demethylases that catalyze the demethylation of H3K27me2/3. The role and mechanisms of both JMJD3 and UTX have been extensively studied for their involvement in development, cell plasticity, immune system, neurodegenerative disease, and cancer. In this review, we will focus on recent progresses made on understanding JMJD3 in the regulation of gene expression in development and diseases. This article is part of a Directed Issue entitled: Epigenetics dynamics in development and disease.

Burchfield JS ，Li Q ，Wang HY ，Wang RF ... -  《-》

EZH2, JMJD3, and UTX epigenetically regulate hepatic plasticity inducing retro-differentiation and proliferation of liver cells.

Pediconi N ，Salerno D ，Lupacchini L ，Angrisani A ，Peruzzi G ，De Smaele E ，Levrero M ，Belloni L ... -  《Cell Death & Disease》

Regulation of Retinal Development via the Epigenetic Modification of Histone H3.

Watanabe S ，Murakami A 《Advances in Experimental Medicine and Biology》

Identification of JmjC domain-containing UTX and JMJD3 as histone H3 lysine 27 demethylases.

Hong S ，Cho YW ，Yu LR ，Yu H ，Veenstra TD ，Ge K ... -  《-》

Expression and significance of histone H3K27 demethylases in renal cell carcinoma.

Shen Y ，Guo X ，Wang Y ，Qiu W ，Chang Y ，Zhang A ，Duan X ... -  《BMC CANCER》