Automated electrophilic radiosynthesis of [¹⁸F]FBPA using a modified nucleophilic GE TRACERlab FXFDG.

We modified a commercially available synthesis module for nucleophilic [(18)F]fluorinations (TRACERlab(TM) FXFDG, GE Healthcare) to enable the reliable synthesis of 2-[(18)F]fluoro-4-borono-L-phenylalanine ([(18)F]FBPA) via direct electrophilic substitution of 4-borono-L-phenylalanine with [(18)F]F2 gas. [(18)F]FBPA was obtained with a RCY of 8.5±2.0% and a radiochemical purity of 98±1% in a total synthesis time of 72±7 min (n=22). The modified synthesis module might also be useful for the synthesis of other [(18)F]radiopharmaceuticals via electrophilic substitution reactions while still being suitable for nucleophilic substitution reactions.

Mairinger S ，Stanek J ，Wanek T ，Langer O ，Kuntner C ... -  《-》

Automated radiosynthesis of [(18)F]ciprofloxacin.

We transferred the previously published manual synthesis of [(18)F]ciprofloxacin (decay-corrected RCY: 5.5±1.0%) to an automated synthesis module (TRACERlab(TM) FXFDG, GE Healthcare) and observed a strong decrease in RCY (0.4±0.4%). When replacing the standard 15-mL glassy carbon reactor of the synthesis module with a 3-mL V-shaped borosilicate glass reactor a considerable improvement in RCY was observed. [(18)F]Ciprofloxacin was obtained in a RCY of 2.7±1.4% (n=23) with a specific activity at EOS of 1.4±0.5GBq/µmol in a synthesis time of 160min.

Stanek J ，Mairinger S ，Wanek T ，Kuntner C ，Müller M ，Langer O ... -  《-》

Nucleophilic radiosynthesis of boron neutron capture therapy-oriented PET probe [(18)F]FBPA using aryldiboron precursors.

He J ，Yan H ，Du Y ，Ji Y ，Cai F ，Fan W ，Huo L ，Liu YH ，Wang Z ，Li S ... -  《-》

Reliable radiosynthesis of 4-[(10)B]borono-2-[(18)F]fluoro-L-phenylalanine with quality assurance for boron neutron capture therapy-oriented diagnosis.

Ishiwata K ，Ebinuma R ，Watanabe C ，Hayashi K ，Toyohara J ... -  《-》

Automated radiosynthesis of [18F]PBR111 and [18F]PBR102 using the Tracerlab FXFN and Tracerlab MXFDG module for imaging the peripheral benzodiazepine receptor with PET.

[(18)F]PBR111 and [(18)F]PBR102 are selective radioligands for imaging of the Peripheral Benzodiazepine Receptor (PBR). We have developed a fully automated method for the radiosynthesis of [(18)F]PBR111 and [(18)F]PBR102 in the Tracerlab FX(FN) (30±2% radiochemical yield non-decay-corrected for both tracers) and Tracerlab MX(FDG) (25±2% radiochemical yield non-decay-corrected for both tracers) from the corresponding p-toluenesulfonyl precursors. For all tracers, radiochemical purity was >99% and specific activity was >150GBq/μmol after less than 60min of preparation time.

Bourdier T ，Pham TQ ，Henderson D ，Jackson T ，Lam P ，Izard M ，Katsifis A ... -  《-》