Serum brain-derived neurotrophic factor differences between the luteal and follicular phases in premenstrual dysphoric disorder.

We hypothesized that comparison of the serum brain-derived neurotrophic factor (BDNF) levels between women with premenstrual dysphoric disorder (PMDD) and women without PMDD in the luteal and follicular phases of their menstrual cycles would reflect the altered neuromodulator responses that compensate the underlying pathogenesis in PMDD. Twenty-nine participants without PMDD and 20 with PMDD were enrolled in the study. The serum BDNF, estrogen and progesterone levels were assessed at the follicular and luteal phases in their two consecutive menstrual cycles. Participants with PMDD had significantly higher luteal serum BDNF levels than the control subjects. The serum BDNF levels were significantly higher in the luteal phase than in the follicular phase in women with PMDD. The difference in the serum BDNF levels between the luteal and follicular phases were significantly higher in the PMDD patients than in the control. The higher serum BDNF levels in the luteal phase in the PMDD patients may reflect compensatory process that results in subsequent improvement of the PMDD-associated depressive symptoms in the follicular phase. The higher difference in the serum BDNF levels between the phases in PMDD patients may reflect an altered neuromodulator response.

Oral E ，Kirkan TS ，Yildirim A ，Kotan Z ，Cansever Z ，Ozcan H ，Aliyev E ，Gulec M ... -  《-》

Luteal serum BDNF and HSP70 levels in women with premenstrual dysphoric disorder.

Oral E ，Ozcan H ，Kirkan TS ，Askin S ，Gulec M ，Aydin N ... -  《-》

Estrogen, progesterone, cortisol, brain-derived neurotrophic factor, and vascular endothelial growth factor during the luteal phase of the menstrual cycle in women with premenstrual dysphoric disorder.

Ko CH ，Wong TH ，Suen JL ，Lin PC ，Long CY ，Yen JY ... -  《-》

Early- and Late-Luteal-Phase Estrogen and Progesterone Levels of Women with Premenstrual Dysphoric Disorder.

Yen JY ，Lin HC ，Lin PC ，Liu TL ，Long CY ，Ko CH ... -  《-》

5α-Reductase Inhibition Prevents the Luteal Phase Increase in Plasma Allopregnanolone Levels and Mitigates Symptoms in Women with Premenstrual Dysphoric Disorder.

Martinez PE ，Rubinow DR ，Nieman LK ，Koziol DE ，Morrow AL ，Schiller CE ，Cintron D ，Thompson KD ，Khine KK ，Schmidt PJ ... -  《-》