Expression of MicroRNA-325-3p and its potential functions by targeting HMGB1 in non-small cell lung cancer.

MicroRNAs (miRNAs) can function as tumor suppressors and might provide an efficient strategy for annihilating cancer. Nevertheless, the potential role of miR-325-3p in NSCLC is still unknown. Here, we showed that miR-325-3p was decreased and HMGB1 was increased in 107 NSCLC patients. MiR-325-3p inhibition promoted cell invasion and proliferation, while miR-325-3p upregulation inhibited cell invasion and proliferation by using transwell and CCK8 assays. Using a bioinformatics method, we further showed that HMGB1 might be a direct target of miR-325-3p and is negatively regulated by miR-325-3p. Down-regulation of miR-325-3p predicts poor prognosis for NSCLC patients. These findings implied that miR-325-3p regulates cell invasion and proliferation via targeting HMGB1 and may be a potential prognostic marker for NSCLC.

Yao S ，Zhao T ，Jin H 《-》

MiR-142-3p functions as a potential tumor suppressor directly targeting HMGB1 in non-small-cell lung carcinoma.

Xiao P ，Liu WL 《International Journal of Clinical and Experimental Pathology》

The microRNA-325 inhibits hepatocellular carcinoma progression by targeting high mobility group box 1.

Li H ，Huang W ，Luo R 《Diagnostic Pathology》

MicroRNA-187-3p mitigates non-small cell lung cancer (NSCLC) development through down-regulation of BCL6.

Hsa-microRNA-187-3p (miR-187-3p) has recently been discovered having anticancer efficacy in different organs. However, the role of miR-187-3p on non-small cell lung cancer (NSCLC) is still ambiguous. In this study, we investigated the role of miR-187-3p on the development of NSCLC. The results indicated that miR-187-3p was significantly down-regulated in primary tumor tissues and very low levels were found in NSCLC cell lines. Ectopic expression of miR-187-3p in NSCLC cell lines significantly suppressed cell growth as evidenced by cell viability assay and colony formation assay, through inhibition of BCL6. In addition, miR-187-3p induced apoptosis, as indicated by concomitantly with up-regulation of the activities of caspase-3 and caspase-7, and inhibited cellular migration and invasiveness through inhibition of BCL6. Further, oncogene BCL6 was revealed to be a putative target of miR-187-3p, which was inversely correlated with miR-187-3p expression in NSCLC. Taken together, our results demonstrated that miR-187-3p played a pivotal role on NSCLC through inhibiting cell proliferation, migration, invasion, and promoting apoptosis by targeting oncogenic BCL6.

Sun C ，Li S ，Yang C ，Xi Y ，Wang L ，Zhang F ，Li D ... -  《-》

MicroRNA-361-3p suppresses tumor cell proliferation and metastasis by directly targeting SH2B1 in NSCLC.

Chen W ，Wang J ，Liu S ，Wang S ，Cheng Y ，Zhou W ，Duan C ，Zhang C ... -  《JOURNAL OF EXPERIMENTAL & CLINICAL CANCER RESEARCH》