Silencing of long noncoding RNA MALAT1 by miR-101 and miR-217 inhibits proliferation, migration, and invasion of esophageal squamous cell carcinoma cells.

MALAT1, a highly conserved long noncoding RNA, is deregulated in several types of cancers. However, its role in esophageal squamous cell carcinoma (ESCC) and its posttranscriptional regulation remain poorly understood. In this study we provide first evidences that a posttranscriptional regulation mechanism of MALAT1 by miR-101 and miR-217 exists in ESCC cells. This posttranscriptional silencing of MALAT1 could significantly suppress the proliferation of ESCC cells through the arrest of G2/M cell cycle, which may be due to MALAT1-mediated up-regulation of p21 and p27 expression and the inhibition of B-MYB expression. Moreover, we also found the abilities of migration and invasion of ESCC cells were inhibited after overexpression of miR-101, miR-217, or MALAT1 siRNA. This might be attributed to the deregulation of downstream genes of MALAT1, such as MIA2, HNF4G, ROBO1, CCT4, and CTHRC1. A significant negative correlation exists between miR-101 or miR-217 and MALAT1 in 42 pairs of ESCC tissue samples and adjacent normal tissues. Mice xenograft data also support the tumor suppressor role of both miRNAs in ESCCs.

Wang X ，Li M ，Wang Z ，Han S ，Tang X ，Ge Y ，Zhou L ，Zhou C ，Yuan Q ，Yang M ... -  《-》

Up-regulation of long noncoding RNA MALAT1 contributes to proliferation and metastasis in esophageal squamous cell carcinoma.

Hu L ，Wu Y ，Tan D ，Meng H ，Wang K ，Bai Y ，Yang K ... -  《JOURNAL OF EXPERIMENTAL & CLINICAL CANCER RESEARCH》

MicroRNA-30d inhibits the migration and invasion of human esophageal squamous cell carcinoma cells via the post‑transcriptional regulation of enhancer of zeste homolog 2.

Xie R ，Wu SN ，Gao CC ，Yang XZ ，Wang HG ，Zhang JL ，Yan W ，Ma TH ... -  《-》

miR-214 inhibits invasion and migration via downregulating GALNT7 in esophageal squamous cell cancer.

Lu Q ，Xu L ，Li C ，Yuan Y ，Huang S ，Chen H ... -  《-》

Silencing of Long Noncoding RNA SNHG6 Inhibits Esophageal Squamous Cell Carcinoma Progression via miR-186-5p/HIF1α Axis.

Du F ，Guo T ，Cao C 《-》