Trends in Prevalence and Prognosis in Subjects With Acute Chronic Respiratory Failure Treated With Noninvasive and/or Invasive Ventilation.

The pattern and outcome of noninvasive ventilation (NIV) use in patients with acute or chronic respiratory disease other than COPD is not well known. The aims of this study were to investigate trends over time in underlying respiratory diseases, use of NIV, and outcomes in COPD and non-COPD patients with acute respiratory failure. We made a retrospective analysis of data recorded prospectively from 1,113 subjects admitted between 1998 and 2012. Subject diagnoses were distributed as follows: COPD, n=568 (51%); bilateral bronchiectasis, n=113 (10%); obesity, n=166 (15%); chronic diffuse interstitial lung disease, n=131 (12%); restrictive pulmonary disease, n=113 (10%); and asthma, n=22 (2%). The proportion of subjects with bilateral bronchiectasis significantly decreased (OR 0.91, 95% CI 0.865-0.951, P<.001), whereas the proportion of subjects with obesity increased (OR 1.03, 95% CI 1.001-1.063, P=.049) over time. The use of NIV (OR 1.05, 95% CI 1.010-1.090, P=.01) and the proportion of subjects initially treated with NIV (OR 1.05, 95% CI 1.013-1.094, P=.009) increased significantly in COPD subjects only. Time trend of mortality was not significant (OR 0.98, 95% CI 0.95-1.01, P=.23), whereas the severity of illness in subjects significantly increased. Transition from NIV to invasive mechanical ventilation (IMV) (OR 2.05, 95% CI 1.36-3.11, P=<.001), IMV (OR 10.49, 95% CI 4.88-10.56, P<.001) and diffuse interstitial lung disease (OR 10.63, 95% CI 5.43-20.83, P<.001) were independently associated with death in the ICU. Over time, respiratory diseases have changed in non-COPD subjects and trends in the use and efficacy of NIV differ between COPD and non-COPD subjects. Mortality remained stable while the severity of illness in subjects increased. In COPD and non-COPD subjects, transition from NIV to IMV was associated with a poorer prognosis.

Gacouin A ，Jouneau S ，Letheulle J ，Kerjouan M ，Bouju P ，Fillatre P ，Le Tulzo Y ，Tadié JM ... -  《-》

Comparative effectiveness of noninvasive ventilation vs invasive mechanical ventilation in chronic obstructive pulmonary disease patients with acute respiratory failure.

Tsai CL ，Lee WY ，Delclos GL ，Hanania NA ，Camargo CA Jr ... -  《-》

Performance of noninvasive ventilation in acute respiratory failure in critically ill patients: a prospective, observational, cohort study.

Corrêa TD ，Sanches PR ，de Morais LC ，Scarin FC ，Silva E ，Barbas CS ... -  《BMC Pulmonary Medicine》

Noninvasive ventilation for acute hypercapnic respiratory failure: intubation rate in an experienced unit.

Contou D ，Fragnoli C ，Córdoba-Izquierdo A ，Boissier F ，Brun-Buisson C ，Thille AW ... -  《-》

Reasons for ICU demand and long-term follow-up of a chronic obstructive pulmonary disease cohort.

Takir HB ，Karakurt Z ，Salturk C ，Kargin F ，Balci M ，Yalcinsoy M ，Ozmen I ，Yazicioglu OM ，Gungor G ，Burunsuzoğlu B ，Adiguzel N ... -  《-》