Prognostic evaluations of small size lung cancers by 18F-FDG PET/CT and thin-section CT.

Primary lung cancers have varying prognoses, even for tumors ≤3cm in diameter. Thus, a thorough evaluation is necessary for therapeutic planning. Two imaging biomarkers have been shown to be useful for predicting primary lung cancer prognosis: maximum standardized uptake values (SUVmax) on fluorodeoxyglucose positron emission tomography/computed tomography (PET/CT) and the consolidation/tumor (C/T) ratio defined as the maximum diameter of consolidation within a tumor to the maximum tumor diameter on thin-section computed tomography (TSCT). We compared these biomarkers for predicting post-surgical recurrence in patients with small lung cancers. Clinical records, post-operative pathologic findings, and pre-operative PET/CT and TSCT images were reviewed. Solitary primary lung cancers of ≤3cm in diameter after surgical resection were selected for analysis. SUVmax and C/T ratios were recorded. Kaplan-Meier survival curves and Cox hazards ratios were used to identify independent predictors of lung cancer recurrence from among age, gender, surgical procedure, lesion size, C/T ratio, and SUVmax. A total of 169 patients (114 males and 55 females; age range: 34-87 years) with solitary lung cancers were evaluated. The median post-operative follow-up period was 42 months. Twenty-eight patients had cancer recurrence with significantly higher SUVmax (p<0.001) and C/T ratios (p<0.001) than patients without recurrence. Disease-free survival was significantly reduced for SUVmax of ≥2.5 vs. SUVmax of <2.5 (p<0.001) or for a C/T ratio of ≥50% vs. a C/T ratio of <50% (p=0.030). For 19 patients with C/T ratios of <50%, none had a post-operative recurrence. A Cox hazards ratio model showed that only SUVmax was an independent predictor of recurrence (hazards ratio=1.324; p<0.001). SUVmax on FDG-PET/CT was a significant imaging biomarker relevant to the prognosis of patients with lung cancers, and was superior to the C/T ratio on TSCT for predicting postoperative recurrence, particularly for solid type lung cancer.

Kishimoto M ，Iwano S ，Ito S ，Kato K ，Ito R ，Naganawa S ... -  《-》

Prognostic value of SUVmax and metabolic tumor volume on 18F-FDG PET/CT in early stage non-small cell lung cancer patients without LN metastasis.

Yoo IeR ，Chung SK ，Park HL ，Choi WH ，Kim YK ，Lee KY ，Wang YP ... -  《-》

Correlation between FDG-PET/CT findings and solid type non-small cell cancer prognostic factors: are there differences between adenocarcinoma and squamous cell carcinoma?

Ito R ，Iwano S ，Kishimoto M ，Ito S ，Kato K ，Naganawa S ... -  《-》

Prognostic value of metabolic tumor volume and total lesion glycolysis from ¹⁸F-FDG PET/CT in patients undergoing stereotactic body radiation therapy for stage I non-small-cell lung cancer.

Vu CC ，Matthews R ，Kim B ，Franceschi D ，Bilfinger TV ，Moore WH ... -  《-》

[Primary tumor SUVmax measured on (18)F-FDG PET-CT correlates with histologic grade and pathologic stage in non-small cell lung cancer].

Zhao SJ ，Wu N ，Zheng R ，Liu Y ，Zhang WJ ，Liang Y ，Zhang H ，Li XM ... -  《-》