Ethnopharmacological analysis of medicinal plants and animals used in the treatment and management of pain in Mauritius.

Pain is a multi-faceted and multi-factorial condition which is challenging to manage and treat. Conventional therapies such as analgesics, Non-steroidal anti-inflammatory drugs (NSAIDs), and corticosteroids amongst others have been successful to some extent in its management and treatment. Nonetheless, such therapies tend to be accompanied by undesirable effects and have a limited therapeutic range. Consequently, there is a pressing need to probe for novel analgesic and anti-nociceptive drugs from traditional medicines (TM). This study was designed to record, document and analyze herbal and animal-based therapies used for the management and treatment of pain in the tropical of Mauritius. Data was collected via face-to-face interviews with TM users (n=332) and practitioners (n=20). Seven quantitative ethnopharmacological indexes, namely family use value (FUV), use value (UV), informant agreement ratio (IAR), relative frequency of citation (RFC), fidelity level (FL), relative importance (RI) and ethnobotanicity index (EI) were calculated. A total of 79 plant species distributed within 40 families and 20 polyherbal preparations was recorded. Interestingly, 6 indigenous/endemic plants have been reported for the first time to be in common use for pain management and treatment in Mauritius. The most significant biologically important plant family was Xanthorrhoeaceae with highest FUV. The species which ranked highest according to its UV was Morinda citrifolia L. Morinda citrifolia L. and Ricinus communis L. also scored the highest RFC. The IAR values for the disease categories were high (0.95-0.97). Based on EI, plants species which are known to be useful in TM accounted for 11.5% of the total flora in Mauritius. Coix lacryma-jobi L. (FL=100%) had highest FL for lower back ache. Morinda citrifolia L. scored highest on most of the quantitative indices calculated including RI, which is endorsed by extensive documentation on its versatility and particularly its anti-nociceptive properties. Seven animal species were recorded to be in common use. The present ethnopharmacological study revealed a panoply of TM to be in common use for pain management and treatment in Mauritius. This study has documented for the first time medicinal plants and animal species with potential analgesic and/or anti-nociceptive properties. This study has therefore provided important baseline primary data for the discovery of new lead molecules for drug development geared towards pain management and treatment.

Sreekeesoon DP ，Mahomoodally MF 《-》

Ethnomedicinal application of native remedies used against diabetes and related complications in Mauritius.

Notoriously, the tropical island of Mauritius has one of the highest prevalence of diabetes worldwide and the economic burden associated with it is alarming. The use of native remedies (NRs) is well anchored in the local culture and it continues to be the cornerstone of therapy for diabetic patients. However, there is currently a dearth of updated primary data on NRs used by Mauritians against diabetes and diabetes related complications (DRCs). This study was therefore designed to record, analyze and document orally transmitted ethnopharmacological knowledge from diabetic patients and traditional medicine practitioners (TMPs) in Mauritius concerning NRs commonly used against diabetes and DRCs which might open new avenues to initiate novel antidiabetic drugs discovery. Data was collected following interviews from diabetic patients (n=328) and TMPs (n=20). Eleven quantitative indexes, namely informant consensus factor (FIC), fidelity level (FL), use value (UV), relative frequency of citation (RFC), relative importance (RI), cultural importance index (CII), index of agreement on remedies (IAR), cultural agreement index (CAI), quality use value (QUV), quality use agreement value (QUAV) and ethnobotanicity index (EI) were calculated. Statistical analysis such as Pearson correlation and Chi-squared test were performed to determine any association. A total of 111 plant species distributed over 56 families, 30 polyherbal formulations and 16 animal species were documented to be traditionally used against diabetes and DRCs. For the first time 8 endemic plants have been recorded to be used against diabetes and DRCs from Mauritius. The most encountered medicinal plant family was Asteraceae. According to the EI, 16.2% of the native plants in Mauritius were used against diabetes and DRCs. As far as we know, Vangueria madagascariensis, Apium graveolens, Petroselinum crispum and Rubus alceifolius with high RFC values are recorded against diabetes and DRCs for the first time. Sociodemographic characteristics (age, gender, income, religious belief, education and residence) were found to significantly (p<0.05) influence the use of NRs. The average FIC for all ailments for plant and animal products were 0.94 and 0.87 respectively. Bryophyllum pinnatum, a native plant to Mauritius scored a high FL value (100%) used against diabetic neuropathy, Allium sativum had the highest RI value (2.00) due to its versatility, Aloe vera had the highest RFC (0.61), the CII (0.640) and the highest CAI value (0.635), Psidium guajava had the highest QUAV (0.961) which indicates its high bioactivity and Allium cepa was reported as the most effective plant species (QUV=0.965). According to UV, the most important species was Morinda citrifolia (1.21). Panoply of animal products were reported whereby fish (39.7%) was recorded as the most utilised zootherapy and Salmo salar scored the highest FL (100%) for diabetes. Some animal species (n=14) not previously documented against diabetes and DRCs are reported in the present study. Our present investigation revealed that the use of NRs constitutes the common legacy of Mauritians and despite the penetration of allopathic medicine; NRs continue to play a crucial role in the primary health care system of Mauritius. To this effect, it is of uttermost importance to record this knowledge before it disappears. In addition, further experimental investigations are required to elucidate the pharmacological properties of the reported medicinal flora and fauna of Mauritius.

Mootoosamy A ，Fawzi Mahomoodally M 《-》

Ethnopharmacological appraisal of culturally important medicinal plants and polyherbal formulas used against communicable diseases in Rodrigues Island.

The tropical island of Rodrigues is one of three islands that constitute the Mascarene archipelago in the Indian Ocean. Currently considered as a biodiversity hotspot, the island has also a resilient history in the use of traditional medicine. However, there has been no ethnopharmacological study to document quantitatively such traditional practice against communicable diseases (CD), which currently accounts for 6.61% annual death and 30.7% attendances in public hospitals. The aim of the present study was to collect, analyse, and document traditionally used medicinal plants (MP) and polyherbal formulas from key informants and traditional medicine practitioners (TMP) in Rodrigues to treat and/or manage common CD. Data was collected via face-to-face interviews with MP users (n=113) and TMP (n=9) from 17 key sites. Seven quantitative ethnopharmacological indices, namely family use value (FUV), use value (UV), informant agreement ratio (IAR), relative frequency of citation (RFC), fidelity level (FL), relative importance (RI), and ethnobotanicity index (EI) were calculated. Ninety-seven plants belonging to 49 families were recorded to be in common use as monotherapy (80 plants) and/or as part of polyherbal preparation (23 plants) for the treatment and/or management of 16 different CD. Thirteen MPs were found to have a maximum FL of 100% for CD. The highest IAR (0.98) was observed for diseases of the eye and adnexa and skin and subcutaneous tissue. The highest FUV was for Arecaceae. Ayapana triplinervis (Vahl) R.M. king et H.Rob. scored the highest UV (UV=2.72). Seven endemic medicinal plants have been recorded to be employed in cultural rituals for the management of common CDs, whereas 14 polyherbal preparations were used to treat and/or manage 6 different types of CDs. Side effects were also reported following use of some these medicinal plants. Given the dearth of updated information on traditional medicine from Rodrigues, this work has provided an opportunity to establish valuable primary information on the different MP used by the local people. Further research is needed to probe into the possible active constituents that could open new perspectives for further pharmacological research and hence be the basis of an evidence-based investigation to discover new drugs.

Samoisy AK ，Mahomoodally F 《-》

Ethnopharmacological analysis of medicinal plants used against non-communicable diseases in Rodrigues Island, Indian Ocean.

Rodrigues is an autonomous outer island that form part of the Republic of Mauritius and one of three islands that constitute the Mascarene archipelago in the Indian Ocean. Though herbal medicine is in common use in Rodrigues, there has been no ethnopharmacological study to document quantitatively such traditional practise particularly against non-communicable diseases (NCD) which is currently a growing major health issue on the island. The aim of the present study was to collect, analyse and document traditionally used medicinal plants (MP) from key informants and traditional medicine practitioners (TMP) in the tropical island of Rodrigues to treat and/or manage common NCD. Data was collected via face-to-face interviews with MP users (n=113) and TMP (n=9). Seven quantitative ethnopharmacological indices, namely family use value (FUV), use value (UV), informant agreement ratio (IAR), relative frequency of citation (RFC), fidelity level (FL), relative importance (RI) and ethnobotanicity index (EI) were calculated. Hundred and three plants belonging to 55 families were recorded for the treatment and/or management of 27 different NCD. Three of the MP (Terminalia bentzoë (L.) L.F, Sarcostemma cf. adontolepis Balf.f. and Clerodendrum laciniatum Balf.f.) recorded are endemic to Rodrigues and 2 (Carissa xylopicron Thouars., Phyllanthus casticum Willemet f.) endemic to the Mascarene Islands. The most solicited MP family was Asteraceae with a total of 8 species. Citrus aurantifolia (Christm.) Swingle scored the highest RFC (RFC=1.02) value. Ten plants were found to score 100% FL and the highest IAR (0.98) was observed for the disease category of certain conditions originating in the perinatal period. Arecaceae scored the highest FUV value and Ayapana triplinervis (Vahl) R.M. King et H.Rob highest UV (UV= 2.72). Given the dearth of updated information on traditional medicine of Rodrigues, this study can provide an opportunity to establish valuable primary information on the different MP used by the local people and hence can open new perspectives for further pharmacological research.

Samoisy AK ，Mahomoodally MF 《-》

Ethnopharmacological survey of native remedies commonly used against infectious diseases in the tropical island of Mauritius.

Infectious diseases (IDs) still remain a major cause of mortality and morbidity worldwide. This study has been geared to gather primary ethnopharmacological information on common native remedies (NRs) used to treat and/or manage common infectious diseases from different regions of Mauritius, a tropical multicultural island in the Indian Ocean. Given the dearth of updated information on traditional medicine of Mauritius, this work can provide an opportunity to establish valuable primary information on the different NRs used by the local people and hence open new perspectives for further pharmacological research. To collect, preserve and document primary ethnopharmacological data from the local population concerning NRs commonly used against IDs in the tropical island of Mauritius. Face to face interviews were conducted with Mauritians and herbalists (n=307) using a semi-structured questionnaire. Quantitative ethnobotany parameters such as informant consensus factor (F(IC)), fidelity level (FL), use value (UV) and variety of use (VU) were used for herbal and animal products. Statistical analysis such as Pearson correlation and Chi-squared test were performed to delineate any association. It was found that 94.8% of the local people claimed that managing IDs with NRs was part of their culture and have been using it since childhood. A total of 39 plant species belonging to 24 families and 9 animal species were reported to be traditionally used in the formulation of herbal remedies and animal products, respectively. Sociodemographic characteristics (gender, age, place of residence and income) had a significant (p<0.01) impact on the use of these NRs. The most relevant family contributing much to the medicinal flora was Zingiberaceae (No of citation=301). The average F(IC) for all ailments for medicinal plants and animal products were 0.963 and 0.972, respectively. Acalypha indica L. had the highest FL (0.83) for skin and subcutaneous tissue problems. Panoply of animal products (Anguilla japonica, Periplaneta americana and Helix aspersa) were culturally used, whereby products from Bos taurus, (42.0%) were the most utilized zootherapy. Other remedies used in concurrence with herbal and animal products involved cultural rituals and prayers that were never reported in previous studies. Therapeutic properties of some herbal remedies reported correlated to some extent with those of previous studies while others have open potential perspectives for further research as their chemistry and pharmacology have not been published. Given the plethora of novel information obtained from the present survey, it is obvious that the indigenous population still relies to a great extent on NRs which need to be preserved and used sustainably. Nonetheless, further research is needed to probe the possible active constituents that could be the basis of an evidence based investigation to discover new drugs.

Nunkoo DH ，Mahomoodally MF 《-》