Prevention of carbon tetrachloride (CCl4)-induced toxicity in testes of rats treated with Physalis peruviana L. fruit.

Treatment of rats with carbon tetrachloride (CCl4; 2 ml/kg body weight) once a week for 12 weeks caused a significant decrease in serum levels of testosterone, luteinizing hormone, and follicle-stimulating hormone. These decreases in sex hormones were reduced with Physalis peruviana L. (Cape gooseberry) juice supplementation. In addition, testicular activity of antioxidant enzymes such as superoxide dismutase, catalase, glutathione peroxidase, glutathione reductase, and glutathione-S-transferase suppressed with CCl4 were elevated after P. peruviana juice supplements. P. peruviana juice supplementation significantly increased the testicular glutathione and significantly decreased the level of lipid peroxidation and the nitric oxide production compared with the CCl4 group. In addition, the decline in the activity of antioxidant enzymes after CCl4 was ameliorated by P. peruviana Moreover, degeneration of germ and Leydig cells along with deformities in spermatogenesis induced after CCl4 injections were prevented with the supplementation of P. peruviana juice. Furthermore, P. peruviana juice attenuated CCl4-induced apoptosis in testes tissue by inhibition of caspase-3 activity. The results clearly demonstrate that P. peruviana juice augments the antioxidants defense mechanism against CCl4-induced reproductive toxicity and provides evidence that the juice may have a therapeutic role in free radical-mediated diseases and infertility.

Abdel Moneim AE 《-》

Protective effects of pomegranate (Punica granatum) juice on testes against carbon tetrachloride intoxication in rats.

Al-Olayan EM ，El-Khadragy MF ，Metwally DM ，Abdel Moneim AE ... -  《BMC Complementary and Alternative Medicine》

The Beneficial Effect of Cape Gooseberry Juice on Carbon Tetrachloride- Induced Neuronal Damage.

Al-Olayan EM ，El-Khadragy MF ，Omer SA ，Shata MT ，Kassab RB ，Abdel Moneim AE ... -  《-》

The potential protective effect of Physalis peruviana L. against carbon tetrachloride-induced hepatotoxicity in rats is mediated by suppression of oxidative stress and downregulation of MMP-9 expression.

Al-Olayan EM ，El-Khadragy MF ，Aref AM ，Othman MS ，Kassab RB ，Abdel Moneim AE ... -  《-》

Effect of Physalis peruviana L. on cadmium-induced testicular toxicity in rats.

Othman MS ，Nada A ，Zaki HS ，Abdel Moneim AE ... -  《-》