The spectra, symptom profiles and overlap of Rome III functional gastrointestinal disorders in a tertiary center in South China.

Most previous studies exploring the overlap of functional gastrointestinal disorders (FGID) focus on the overlap between functional dyspepsia (FD) and irritable bowel syndrome (IBS). In this study, we aimed to explore the spectra, symptom profiles and overlap of all FGID using the validated Chinese version of the Rome III questionnaire. Consecutive newly diagnosed FGID patients who were admitted to the Outpatient Gastroenterology Clinic from 10 May to 10 September 2012 were recruited in the study. All the patients complained of gastrointestinal (GI) symptoms for at least 3 months with a symptom onset of at least 6 months before diagnosis after excluded organic diseases. Patients who met the inclusion criteria were asked to complete the scoring algorithm for the Rome III integrated questionnaire. Among 350 eligible patients, 302 (86.3%) returned completed questionnaires. A total of six major domains including 17 disorders were diagnosed. The four most prevalent FGID were FD (54.6%), IBS (40.7%), unspecified functional bowel disorder (13.9%) and functional constipation (12.6%). The three most prevalent symptoms in FGID were abdominal pain (66.2%), loose stool (58.3%) and abdominal bloating/distension (56.3%). Of the 302 patients, 152 (50.3%) had one to five overlapping FGID. Only functional bloating had no overlap. Six patients had five overlapping FGID simultaneously. In all, 63 patients had overlapping FD and IBS. This study provided the detailed spectra and symptom profiles for all FGID. Overlapping FGID are common in China.

Xiong LS ，Shi Q ，Gong XR ，Cui Y ，Chen MH ... -  《-》

Spectra of functional gastrointestinal disorders diagnosed by Rome III integrative questionnaire in a Japanese outpatient office and the impact of overlapping.

Nakajima S ，Takahashi K ，Sato J ，Fukuda M ，Yamamoto K ，Inoue T ，Okumura Y ，Fujiyama Y ... -  《-》

The overlap of upper functional gastrointestinal disorders with irritable bowel syndrome in Chinese outpatients: A multicenter study.

Irritable bowel syndrome (IBS) is a common functional bowel disease, and the overlap with upper functional gastrointestinal disorders (FGIDs) is popular. However, the coexistent upper GI symptom profiles, upper FGID spectra, and related risk factors among IBS subjects remain unclear in mainland of China. Consecutive patients from the outpatient gastroenterology clinics of three tertiary hospitals in China were enrolled in this multicenter study. All upper GI symptoms occurring at least once a week in the last 3 months were recorded. Diagnostic criteria of functional esophageal, gastroduodenal disorders and IBS were based on Rome III criteria. Risk factors were assessed using a multivariate logistic regression model. Of the 8906 consecutive patients, 751 patients met Rome III criteria for IBS and 735 IBS patients participated in the interview. Postprandial fullness (30.6%), belching (27.1%), and regurgitation (21.8%) were the three most prevalent upper GI symptoms in IBS. Functional dyspepsia (FD, 36.7%), belching disorders (27.1%), and functional heartburn (16.3%) were the three most frequent upper FGID in IBS patients. Female sex, divorced or widowed versus married status, defecation straining, reduced bowel movement, mixed IBS, abdominal distention, mild abdominal pain, moderate discomfort were positively associated with IBS-FD overlap. Female sex, drinking, moderate discomfort, and mild to moderate distension were independent risk factors for IBS-belching disorder overlap. The study provides detailed overlap spectra of upper FGID with IBS. Mixed IBS is an important risk factor for IBS-FD overlap, which deserved more concern.

Yao X ，Yang YS ，Cui LH ，Sun G ，Peng LH ，Wang WF ，Hyder Q ，Zhang XL ... -  《-》

The spectra of functional gastrointestinal disorders (FGID) in a Japanese hospital outpatient department according to the ROME II Integrative Questionnaire.

Nakajima S 《-》

The clinical overlap between functional dyspepsia and irritable bowel syndrome based on Rome III criteria.

Wang A ，Liao X ，Xiong L ，Peng S ，Xiao Y ，Liu S ，Hu P ，Chen M ... -  《BMC GASTROENTEROLOGY》