Plasmid carriage of bla NDM-1 in clinical Acinetobacter baumannii isolates from India.

NDM-1 probably emerged in Acinetobacter species prior to its dissemination among Enterobacteriaceae, and NDM-1-like enzymes are increasingly reported in Acinetobacter species. Here, we report on the genetic context of blaNDM-1 in the earliest known NDM-1-producing organisms, clinical isolates of Acinetobacter from India in 2005. These strains harbor blaNDM-1 plasmids of different sizes. The gene is associated with the remnants of the Tn125 transposon normally associated with blaNDM-1 in Acinetobacter spp. The transposon has been disrupted by the IS26 insertion and subsequent movement events.

Jones LS ，Toleman MA ，Weeks JL ，Howe RA ，Walsh TR ，Kumarasamy KK ... -  《-》

Molecular characterization of blaNDM-1 in an Acinetobacter baumannii strain isolated in Germany in 2007.

Pfeifer Y ，Wilharm G ，Zander E ，Wichelhaus TA ，Göttig S ，Hunfeld KP ，Seifert H ，Witte W ，Higgins PG ... -  《-》

Tn125-related acquisition of blaNDM-like genes in Acinetobacter baumannii.

Poirel L ，Bonnin RA ，Boulanger A ，Schrenzel J ，Kaase M ，Nordmann P ... -  《-》

Distinct Mechanisms of Dissemination of NDM-1 Metallo-β-Lactamase in Acinetobacter Species in Argentina.

A 4-year surveillance of carbapenem-resistant Acinetobacter spp. isolates in Argentina identified 40 strains carrying blaNDM-1 Genome sequencing revealed that most were Acinetobacter baumannii, whereas seven represented other Acinetobacter spp. The A. baumannii genomes were closely related, suggesting recent spread. blaNDM-1 was located in the chromosome of A. baumannii strains and on a plasmid in non-A. baumannii strains. A resistance gene island carrying blaPER-7 and other resistance determinants was found on a plasmid in some A. baumannii strains.

Adams MD ，Pasteran F ，Traglia GM ，Martinez J ，Huang F ，Liu C ，Fernandez JS ，Lopez C ，Gonzalez LJ ，Albornoz E ，Corso A ，Vila AJ ，Bonomo RA ，Ramirez MS ... -  《-》

Dissemination of New Delhi metallo-β-lactamase-1-producing Acinetobacter baumannii in Europe.

Multidrug-resistant and New Delhi metallo-β-lactamase 1 (NDM-1) -producing Acinetobacter baumannii are increasingly reported. A collection of five NDM-1-positive A. baumannii isolates recovered in four European countries were analysed. Genotyping was performed by pulsed-field gel electrophoresis, multiplex PCR sequence typing, Diversilab and multilocus sequence typing. Three distinct sequence types were identified. All isolates harboured a chromosomally located bla(NDM-1) gene within a Tn125-like transposon. One isolate co-expressed another unrelated carbapenemase OXA-23. This report constitutes the first epidemiological study of NDM-1-producing A. baumannii from four countries.

Bonnin RA ，Poirel L ，Naas T ，Pirs M ，Seme K ，Schrenzel J ，Nordmann P ... -  《-》