New sesquiterpenic acids from Inula wissmanniana.

Eight new (1-8) and two known (9 and 10) sesquiterpenic acids featuring α-methylene-γ-carboxyl units were isolated from the whole plants of Inula wissmanniana, along with two new germacranolides (11 and 12). Their structures were elucidated based on detailed spectroscopic analysis, including HRESIMS, 1D and 2D NMR, and X-ray crystallography. Notably, the skeleton of 1 was firstly discovered from nature, while that of 2 was discovered for the second time. All the compounds were evaluated for their inhibition against LPS-induced nitric oxide (NO) production in RAW264.7 macrophages. Compound 11 exhibited the strongest activity with the IC50 value of 1.04 μM.

Cheng XR ，Wang CH ，Wei PL ，Zhang XF ，Zeng Q ，Yan SK ，Jin HZ ，Zhang WD ... -  《-》

Sesquiterpene lactones from Inula hupehensis inhibit nitric oxide production in RAW264.7 macrophages.

Phytochemical investigation of the aerial parts of Inula hupehensis Ling. led to the isolation and identification of 27 sesquiterpene lactones (1-27), including three new eudesmanolides (3-5), three new germacranolides (9-11), one new xanthanolide (16), two new carabrone derivatives (25-26), and 18 known sesquiterpene lactones. The structures were elucidated by extensive spectroscopic methods and comparison to previously reported spectroscopic data. All compounds were evaluated for their inhibitory effects against LPS-induced nitric oxide production in RAW264.7 macrophages, and compound 5 showed the strongest activity with the IC₅₀ value of 3.2 ± 0.4 µM.

Qin JJ ，Zhu JX ，Zeng Q ，Cheng XR ，Zhang SD ，Jin HZ ，Zhang WD ... -  《-》

Bioactive eudesmane and germacrane derivatives from Inula wissmanniana Hand.-Mazz.

Phytochemical investigation of Inula wissmanniana Hand.-Mazz. afforded 21 eudesmane and germacrane derivatives, including rare 4,5-secoeudesman-12,5-olide, eudesman-12,5-olide, 3,4-secoeudesman-12-oic acid, and germacra-4-en-12,6-olides. Their structures were elucidated by combinative analyses of MS, NMR, electronic circular dichroism, and X-ray crystallography data. Moreover, most of the isolates exhibited inhibition against lipopolysaccharide-induced nitric oxide production in RAW264.7 macrophages and cytotoxicity in HepG2, PC-3, and MGC-803 tumor cells.

Cheng XR ，Zhang SD ，Wang CH ，Ren J ，Qin JJ ，Tang X ，Shen YH ，Yan SK ，Jin HZ ，Zhang WD ... -  《-》

Five new sesquiterpene lactones from Inula hupehensis.

Ren J ，Qin JJ ，Cheng XR ，Yan SK ，Jin HZ ，Zhang WD ... -  《-》

Sesquiterpenes from Inula japonica with Inhibitory Effects on Nitric Oxide Production in Murine Macrophage RAW 264.7 Cells.

Jin Q ，Lee JW ，Jang H ，Choi JE ，Lee D ，Hong JT ，Kim Y ，Lee MK ，Hwang BY ... -  《-》