Biodegradable polymeric vesicles containing magnetic nanoparticles, quantum dots and anticancer drugs for drug delivery and imaging.

We have developed biodegradable polymeric vesicles as a nanocarrier system for multimodal bio-imaging and anticancer drug delivery. The poly(lactic-co-glycolic acid) (PLGA) vesicles were fabricated by encapsulating inorganic imaging agents of superparamagnetic iron oxide nanoparticles (SPION), manganese-doped zinc sulfide (Mn:ZnS) quantum dots (QDs) and the anticancer drug busulfan into PLGA nanoparticles via an emulsion-evaporation method. T2∗-weighted magnetic resonance imaging (MRI) of PLGA-SPION-Mn:ZnS phantoms exhibited enhanced negative contrast with r2∗ relaxivity of approximately 523 s(-1) mM(-1) Fe. Murine macrophage (J774A) cellular uptake of PLGA vesicles started fluorescence imaging at 2 h and reached maximum intensity at 24 h incubation. The drug delivery ability of PLGA vesicles was demonstrated in vitro by release of busulfan. PLGA vesicle degradation was studied in vitro, showing that approximately 32% was degraded into lactic and glycolic acid over a period of 5 weeks. The biodistribution of PLGA vesicles was investigated in vivo by MRI in a rat model. Change of contrast in the liver could be visualized by MRI after 7 min and maximal signal loss detected after 4 h post-injection of PLGA vesicles. Histological studies showed that the presence of PLGA vesicles in organs was shifted from the lungs to the liver and spleen over time.

Ye F ，Barrefelt A ，Asem H ，Abedi-Valugerdi M ，El-Serafi I ，Saghafian M ，Abu-Salah K ，Alrokayan S ，Muhammed M ，Hassan M ... -  《-》

Biodistribution of biodegradable polymeric nano-carriers loaded with busulphan and designed for multimodal imaging.

Asem H ，Zhao Y ，Ye F ，Barrefelt Å ，Abedi-Valugerdi M ，El-Sayed R ，El-Serafi I ，Abu-Salah KM ，Hamm J ，Muhammed M ，Hassan M ... -  《JOURNAL OF NANOBIOTECHNOLOGY》

Luminescent/magnetic PLGA-based hybrid nanocomposites: a smart nanocarrier system for targeted codelivery and dual-modality imaging in cancer theranostics.

Shen X ，Li T ，Chen Z ，Geng Y ，Xie X ，Li S ，Yang H ，Wu C ，Liu Y ... -  《International Journal of Nanomedicine》

Design of hybrid multimodal poly(lactic-co-glycolic acid) polymer nanoparticles for neutrophil labeling, imaging and tracking.

Qiu Y ，Palankar R ，Echeverría M ，Medvedev N ，Moya SE ，Delcea M ... -  《-》

Effects of particle size and surface coating on cellular uptake of polymeric nanoparticles for oral delivery of anticancer drugs.

Win KY ，Feng SS 《-》