Role of EZH2 in oral squamous cell carcinoma carcinogenesis.

Oral squamous cell carcinoma (OSCC) is a common human malignancy with high incidence rate and poor prognosis. Although the polycomb group protein enhancer of zeste homolog 2 (EZH2) plays a crucial role in cell proliferation and differentiation during the occurrence and development progress of several kinds of malignant tumors, the impact of EZH2 on the development and progression of OSCC is unclear. In this study, we demonstrate that EZH2 is overexpressed in OSCC cells and clinical tissue. With in vitro RNAi analysis, we generated stable EZH2 knocking down cell lines from two OSCC cell lines, with two sh-RNAs targeting to EZH2, respectively. We found that knocking down of EZH2 could decrease the proliferation ability and induce apoptosis of OSCC cells. Moreover, we demonstrated that of EZH2 inhibition decreased the migration and metastasis of OSCC cells. In conclusion, the results of the current study demonstrated an association between EZH2 expression and OSCC cell development. We recommend that EZH2 acts as an oncogene and plays an important role in OSCC carcinogenesis.

Zhao L ，Yu Y ，Wu J ，Bai J ，Zhao Y ，Li C ，Sun W ，Wang X ... -  《-》

LncRNA HOXA-AS2 Promotes Oral Squamous Cell Proliferation, Migration, and Invasion via Upregulating EZH2 as an Oncogene.

Zhao Z ，Xing Y ，Yang F ，Zhao Z ，Shen Y ，Song J ，Jing S ... -  《-》

MiR-32 functions as a tumor suppressor and directly targets EZH2 in human oral squamous cell carcinoma.

Zhang D ，Ni Z ，Xu X ，Xiao J ... -  《MEDICAL SCIENCE MONITOR》

Long non-coding RNA HOTAIR promotes tumor cell invasion and metastasis by recruiting EZH2 and repressing E-cadherin in oral squamous cell carcinoma.

Wu Y ，Zhang L ，Zhang L ，Wang Y ，Li H ，Ren X ，Wei F ，Yu W ，Liu T ，Wang X ，Zhou X ，Yu J ，Hao X ... -  《-》

Aberrant expression of EZH2 is associated with pathological findings and P53 alteration.

Shiogama S ，Yoshiba S ，Soga D ，Motohashi H ，Shintani S ... -  《-》