Extraglandular manifestations of primary Sjögren's syndrome.

Sjögren syndrome is a chronic autoimmune disease that typically affects the salivary and lacrimal glands. Aside from the common glandular signs and symptoms, Sjögren syndrome may also cause mononuclear infiltration and immune complex deposition involving extraglandular sites producing several extraglandular manifestations (EGM). The prevalence of EGMs varies greatly depending on the particular manifestation. This article examines the ways that EGMs may present in patients with primary Sjögren syndrome. The focus is on the more prevalent and significant EGMs including involvement of the nervous system, pulmonary manifestations, vasculitis associated with primary Sjögren syndrome, and arthropathy.

Ienopoli S ，Carsons SE 《-》

Management of extraglandular manifestations of primary Sjögren's syndrome.

Primary Sjögren's syndrome can have multiple extra-glandular manifestations ranging from mild to severe. Treatment for extra-glandular manifestations is organ specific and therapies are targeted based on the primary organs involved. Preferred treatment options used for extra-glandular manifestations of Sjögren's syndrome are usually extrapolated from the physician's experience in treating similar manifestations in other autoimmune conditions such as rheumatoid arthritis and systemic lupus erythematous. The lack of immunomodulating disease modifying drugs in Sjögren's syndrome can be frustrating for patients dealing with extra-glandular manifestations, however recent advances in the field has made the future look promising for new therapeutic options.

Wu JJ ，Carsons SE 《-》

Autoimmune cholangitis in patients with primary Sjögren's syndrome. A case report.

Agoşton-Coldea L ，Fodor D ，Pais R ，Rusu ML ，Georgiu C ... -  《-》

Neuro-musculo-skeletal manifestations in primary Sjögren's syndrome.

Kruize AA ，Hené RJ ，Oey PL ，Kater L ，Bijlsma JW ... -  《NETHERLANDS JOURNAL OF MEDICINE》

[Neurologic manifestations of primary Gougerot-Sjögren syndrome].

Lafitte C 《REVUE NEUROLOGIQUE》