Exclusive low-molecular-weight heparin as bridging anticoagulant after mechanical valve replacement.

Unfractionated heparin has been the standard anticoagulant used immediately after mechanical heart valve replacement (MHVR). The purpose of this study was to assess a postoperative anticoagulation protocol with low-molecular-weight heparin (LMWH) immediately after MHVR without the use of unfractionated heparin or anti-factor Xa monitoring. We performed a prospective, single-center, observational study of 1,063 consecutive patients undergoing elective MHVR with postoperative LMWH anticoagulation treatment. The exclusion criteria were as follows: renal failure, intraaortic balloon counterpulsation, critical perioperative state, or a recent neurologic event. The postoperative anticoagulation protocol used subcutaneous enoxaparin as a bridging anticoagulant treatment beginning on the first postoperative day and continuing until vitamin K antagonist treatment was fully effective. Patients were followed for 6 weeks. The primary endpoints were the incidence of thromboembolic or major bleeding events. Eleven (1%) thromboembolic events occurred. Ten of these events were transient or permanent strokes. Major bleeding events occurred in 44 patients (4.1%), 7 of which were observed before the enoxaparin treatment period. At the time of discharge, 570 patients (53.6%) were no longer receiving LMWH treatment due to achieving the target international normalized ratio. The mean length of hospital stay was 8.5 ± 2.9 days. There were no deaths during the 6-week follow-up period. In our highly selected population, after MHVR, postoperative anticoagulation using LMWH is associated with a low rate of thromboembolic and major bleeding events. This large observational study demonstrates that the use of LMWH as an anticoagulant is effective and safe after MHVR.

Kindo M ，Gerelli S ，Hoang Minh T ，Zhang M ，Meyer N ，Announe T ，Bentz J ，Mansour Z ，Mommerot A ，Petit-Eisenmann H ，Kremer H ，Collange O ，Pottecher J ，Cristinar M ，Thiranos JC ，Billaud P ，Mazzucotelli JP ... -  《-》

Low-molecular-weight heparin as a bridging anticoagulant early after mechanical heart valve replacement.

Meurin P ，Tabet JY ，Weber H ，Renaud N ，Ben Driss A ... -  《-》

Comparison of different bridging anticoagulation therapies used after mechanical heart valve replacement in Chinese patients - a prospective cohort study.

Li BX ，Liu SD ，Qi L ，Sun S ，Sun W ，Li YM ，Song B ，Wu XA ... -  《Journal of Cardiothoracic Surgery》

Half-dose enoxaparin vs. full-dose enoxaparin for postoperative bridging therapy in patients after cardiac surgery: which dose regimen should be preferred?

Weiss A ，Brose S ，Ploetze K ，Matschke K ... -  《-》

[Comparison on efficacy and safety of different bridging anticoagulation therapies in patients undergoing mechanical heart valve replacement surgery].

Liu SD ，Qi L ，Li BX ，Li X ，Fang T ，Song B ... -  《-》