Build-a-brain.

A major barrier in understanding nervous system development is modeling the cellular interactions that form the human brain. Recently, in the journal Nature, Lancaster et al. (2013) established a protocol for culturing pluripotent stem cell (PSC)-derived "cerebral organoids" that mimics the developing human brain's cellular organization, segregates into distinct brain regions, and models microcephaly.

Chambers SM ，Tchieu J ，Studer L 《-》

Cerebral organoids in a dish: progress and prospects.

A three-dimensional culture of cortical tissues derived from pluripotent stem cells offers an opportunity to model human brain development and disorders. In a recent issue of Nature, Lancaster et al. describe a new method for generating cerebral organoids in a dish and use it to model microcephaly.

Bershteyn M ，Kriegstein AR 《-》

Cerebral organoids model human brain development and microcephaly.

Hattori N 《-》

Modeling human brain development with cerebral organoids.

Muzio L ，Consalez GG 《Stem Cell Research & Therapy》

Neuroscience. What are mini-brains?

Bae BI ，Walsh CA 《-》