Eudesmane-type sesquiterpene derivatives from Laggera alata.

Ten eudesmane-type sesquiterpene derivatives (1-10), including six cuauhtemone derivatives (1-6), one di-norsesquiterpene (3-oxo-di-nor-eudesma-4-en-11-oic acid, 7), and three eudesmane glycosides (alatoside F-H, 8-10) were isolated from the whole plants of Laggera alata together with 12 known compounds. Their structures were elucidated on the basis of extensive spectroscopic analysis, acid hydrolysis, and compounds 1 and 7 were studied by single-crystal X-ray diffraction analysis. The absolute configuration of 1 was determined by the application of the modified Mosher's method. All of the isolated eudesmane-type sesquiterpenes were evaluated for their cytotoxic activities on six human cancer cell lines, but all of the compounds were inactive on the tested cell lines in the concentration of 100 μg/mL.

Wang GC ，Li GQ ，Geng HW ，Li T ，Xu JJ ，Ma F ，Wu X ，Ye WC ，Li YL ... -  《-》

Eudesmane derivatives and other sesquiterpenes from Laggera alata.

Zheng QX ，Xu ZJ ，Sun XF ，Guéritte F ，Cesario M ，Sun HD ，Cheng CH ，Hao XJ ，Zhao Y ... -  《-》

Laggeric acid, a novel seco-eudesmane sesquiterpenoid from Laggera crispata.

Qiu YH ，Yang YF ，Tan JM ，Tan CH ，Chang J ... -  《-》

New eudesmane-type sesquiterpenoid from Solanum lyratum with cytotoxic activity.

Nie XP ，Yao F ，Yue XD ，Li GS ，Dai SJ ... -  《-》

Sesquiterpenoids from the roots of Vladimiria muliensis.

Chen JJ ，Bai W ，Gobu FR ，Wu CH ，Zeng J ，Sun M ，Gao K ... -  《-》