Diagnostic performance of the biomarkers HE4 and CA125 in type I and type II epithelial ovarian cancer.

To evaluate the diagnostic performance of HE4 and CA125 in patients presenting with suspicious malignant ovarian cysts. We especially wanted to investigate the levels of HE4 and CA125 with regard to the gene and histology-unifying model of type I and type II epithelial ovarian cancer (EOC). Plasma from 373 women presenting with a suspicious malignant ovarian cyst was collected prior to surgery. Histology, grade, and stage were determined according to FIGO-classification. HE4 and CA125 were analyzed using ELISA, and the markers were evaluated for significance separately and in combination. Receiver operating curves, the area under the curve, sensitivity and specificity were estimated. The combination of HE4 and CA125 resulted in the best diagnostic power in comparing benign tumors to EOC (ROC AUC 0.93, sensitivity 94.4% at 75% specificity) for type II. Diagnostic power in type I (ROC AUC 0.79, sensitivity 61.9% at 75% specificity) was less impressive. In particular, mucinous benign vs. malignant tumors could not significantly be separated by the dual marker combination. Impressively high ROC AUC 0.99 was found for the late stage type II EOC with 100% sensitivity at 75% specificity. HE4 and CA125 have a good ability to diagnose the more aggressive type II tumors but a poor diagnostic ability when patients are presenting with slow-growing type I in the early stage. Our results support the hypothesis that EOC should be looked upon as several different diseases, and that we lack biomarkers for sub-groups of EOC.

Kristjansdottir B ，Levan K ，Partheen K ，Sundfeldt K ... -  《-》

Clinical application of HE4 and CA125 in ovarian cancer type I and type II detection and differential diagnosis.

Gąsiorowska E ，Michalak M ，Warchoł W ，Lemańska A ，Jasiński P ，Spaczyński M ，Nowak-Markwitz E ... -  《Ginekologia Polska》

Diagnostic Model of Serum miR-193a-5p, HE4 and CA125 Improves the Diagnostic Efficacy of Epithelium Ovarian Cancer.

Ren X ，Zhang H ，Cong H ，Wang X ，Ni H ，Shen X ，Ju S ... -  《-》

Evaluation of human epididymis protein 4 (HE4) and Risk of Ovarian Malignancy Algorithm (ROMA) as diagnostic tools of type I and type II epithelial ovarian cancer in Japanese women.

Fujiwara H ，Suzuki M ，Takeshima N ，Takizawa K ，Kimura E ，Nakanishi T ，Yamada K ，Takano H ，Sasaki H ，Koyama K ，Ochiai K ... -  《-》

A multiplex biomarker assay improves the diagnostic performance of HE4 and CA125 in ovarian tumor patients.

Leandersson P ，Åkesson A ，Hedenfalk I ，Malander S ，Borgfeldt C ... -  《PLoS One》