A new cytotoxic cembrane diterpene from the roots of Euphorbia pekinensis Rupr.
摘要:
A new cembrane diterpene, named (-)-(1S)-15-hydroxy-18-carboxycembrene, was isolated from petroleum ether extract of the roots of the Euphorbia pekinensis Rupr. To our knowledge, this compound is the first cembrane-type diterpenoid to be found in the family Euphorbiaceae. The structure was elucidated as (-)-(1S)-15-hydroxy-cembra -2E, 4Z, 7E, 11E-tetraen-18-oic acid by a combination of IR, HR-ESIMS, 1D- and 2D-NMR techniques. (-)-(1S)-15-hydroxy-18-carboxycembrene showed cytotoxic activity against all five human cancer cell lines tested.
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DOI:
10.1016/j.fitote.2013.07.004
被引量:
年份:
1970


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