Casbane diterpenoids from the roots of Euphorbia pekinensis.

Four casbane diterpenoids, together with three known related compounds were isolated from the roots of Euphorbia pekinensis. Their structures were elucidated on the basis of spectroscopic studies and comparison with the known related compounds. In addition, the absolute configuration of three compounds was determined by the modified Mosher's method. The isolated compounds were evaluated for their cytotoxic activity against seven human cancer cell lines by a WST-8 assay.

Tao WW ，Duan JA ，Tang YP ，Yang NY ，Li JP ，Qian YF ... -  《-》

A new casbane diterpene from Euphorbia pekinensis.

Wang K ，Yu H ，Wu H ，Wang X ，Pan Y ，Chen Y ，Liu L ，Jin Y ，Zhang C ... -  《-》

Two new casbane diterpenoids from the roots of Euphorbia pekinensis.

Shao FG ，Bu R ，Zhang C ，Chen CJ ，Huang J ，Wang JH ... -  《-》

Lathyrane-type diterpenoids from the seeds of Euphorbia lathyris.

Ten lathyrane-type diterpenoids named Euphorbia Factor L12-L21 (1-10) and twelve known diterpenoids (11-22) were isolated from seeds of Euphorbia lathyris. The structures of these compounds were determined by extensive spectroscopic (UV, IR, HRESIMS, 1D and 2D NMR) analyses. In addition, the configuration of Euphorbia Factor L12 (1) was further confirmed by X-ray crystallographic and circular dichroism (CD) analyses. A putative biogenetic relationship to these compounds was proposed. Cytotoxicity of the isolated compounds against C6 and MCF-7 cell lines were evaluated. Compounds 1, 5, 7, 12 and 17 exhibited considerable cytotoxic activities (IC50 12.4-36.2 μM).

Lu J ，Li G ，Huang J ，Zhang C ，Zhang L ，Zhang K ，Li P ，Lin R ，Wang J ... -  《-》

Diterpenoids with diverse skeletons from the roots of Euphorbia micractina.

Tian Y ，Xu W ，Zhu C ，Lin S ，Guo Y ，Shi J ... -  《-》