Gorham-Stout syndrome affecting the temporal bone with cerebrospinal fluid leakage.

Gorham-Stout syndrome is a rare disorder characterized by progressive osteolysis that leads to the disappearance of bone. Lymphvascular proliferation causes the local destruction of bony tissue. Owing to the low incidence of this syndrome, little is known about its etiology or treatment. We present an 11-year-old girl with Gorham-Stout syndrome that involved right petrous apex in temporal bone and upper clivus, which cause intracranial pressure increase and cerebrospinal fluid (CSF) leakage. The patient required surgical repair of CSF leakage by extradural middle fossa approach with temporal fascia flap. Combined treatment with interferon and propranolol prevented the progression of osteolysis.

Morimoto N ，Ogiwara H ，Miyazaki O ，Kitamuara M ，Nishina S ，Nakazawa A ，Maekawa T ，Morota N ... -  《-》

Gorham-stout syndrome of the petrous apex causing chronic cerebrospinal fluid leak.

Cushing SL ，Ishak G ，Perkins JA ，Rubinstein JT ... -  《-》

Gorham-Stout disease and cerebrospinal fluid otorrhea.

Gorham-Stout disease is a rare entity characterized by vascular proliferation causing local destruction of bone tissue. Owing to its low incidence and variable clinical presentation, the diagnosis requires a high degree of awareness by the clinician. We present the case of a 2-year-old boy diagnosed of Gorham-Stout syndrome with involvement of the temporal bone and secondary cerebrospinal fluid (CSF) leakage. Because of the CSF leakage, the patient required two surgical interventions. The second intervention included mastectomy and placement of a patch and a lumbar drainage device during 50 days, after which the leakage ceased. Gorham-Stout disease is a rare condition that can affect the skull base and even present with CSF leakage.

Hernández-Marqués C ，Serrano González A ，Cordobés Ortega F ，Alvarez-Coca J ，Sirvent Cerda S ，Carceller Lechón F ，Azorín Cuadrillero D ... -  《-》

A case report of Gorham-Stout disease diagnosed during the course of recurrent meningitis and cholesteatoma.

Hosoya M ，Oishi N ，Nishiyama J ，Ogawa K ... -  《Journal of Otolaryngology-Head & Neck Surgery》

Cerebrospinal fluid leakage in Gorham-Stout disease due to dura mater involvement after progression of an osteolytic lesion in the thoracic spine.

Suero Molina EJ ，Niederstadt T ，Ruland V ，Kayser G ，Stummer W ，Ewelt C ，Rössler J ... -  《-》