Cytokine gene polymorphisms in kidney transplantation.

Acute and chronic rejections remain an important cause of graft loss after renal transplantation. It has been suggested that cytokine genotyping may have a predictive role to identify patients at greater risk of rejection regardless of human leukocyte antigen (HLA) compatibility and/or the presence of anti-HLA antibodies before the renal allograft. We sought to investigate polymorphisms of tumor necrosis factor (TNF)-α, transforming growth factor (TGF)-β1, interleukin (IL)-10, IL-6, and interferon (IFN)-γ as indices of differential cytokine production in kidney transplantation and to examine their predictive roles for acute or chronic rejection. TNF-α (G/A -308), TGF -β1 (haplotype codon 10/codon 25), IL-10 (haplotype-1082, -819, -592), IL-6 (C/G -174), and IFN-γ (T/A +874) single nucleotide polymorphisms (SNPs) were detected using polymerase chain reaction (PCR)-specific sequence primers (SSP) in 231 kidney transplant recipients (KTR) including 106 treated with mycophenolate mofetil (MMF+). We observed no significant associations of any of investigated polymorphism taken alone with acute rejection episodes (ARE) or chronic allograft dysfunction (CAD). Nevertheless, TGF-β1 Low (L) production was correlated with greater graft survival at 20 years (81.8%) compared with intermediate (L) or high (H) levels (56.1%), affect that the difference was not significant (P = .2). Cytokine haplotype analysis in KTR (MMF-) without HLA-mismatches or presynthesized anti-HLA antibodies (n = 32) showed ARE to be significantly more prevalent among the TNF-α*H/TGF- β1*H/IL-10*H production haplotype (75%) compared with the other haplotypes (16%; P = .03). The presence of TGF-β1-H secretion profile may protect the kidney graft. TNF-α*H/TGF-β1*H/IL-10*H haplotype was associated with a higher risk of ARE and with poorer graft survival.

Dhaouadi T ，Sfar I ，Bardi R ，Jendoubi-Ayed S ，Abdallah TB ，Ayed K ，Gorgi Y ... -  《-》

Cytokine gene polymorphism in kidney transplantation--impact of TGF-beta 1, TNF-alpha and IL-6 on graft outcome.

Nikolova PN ，Ivanova MI ，Mihailova SM ，Myhailova AP ，Baltadjieva DN ，Simeonov PL ，Paskalev EK ，Naumova EJ ... -  《TRANSPLANT IMMUNOLOGY》

Cytokine gene polymorphisms and acute human liver graft rejection.

Warlé MC ，Farhan A ，Metselaar HJ ，Hop WC ，Perrey C ，Zondervan PE ，Kap M ，de Rave S ，Kwekkeboom J ，Ijzermans JN ，Tilanus HW ，Pravica V ，Hutchinson IV ，Bouma GJ ... -  《LIVER TRANSPLANTATION》

Cytokine single nucleotide polymorphisms and intrarenal gene expression in chronic allograft nephropathy in children.

Melk A ，Henne T ，Kollmar T ，Strehlau J ，Latta K ，Offner G ，Jhangri GS ，Ehrich JH ，Von Schnakenburg C ... -  《-》

TNF-alpha and TGF-beta1 gene polymorphisms and renal allograft rejection in Koreans.

Park JY ，Park MH ，Park H ，Ha J ，Kim SJ ，Ahn C ... -  《-》