Oncogenic role of protein tyrosine kinase 7 in esophageal squamous cell carcinoma.

Esophageal squamous cell carcinoma (ESCC) is a common subtype of esophageal cancer that is particularly prevalent in East Asian countries. Our previous expression profile analysis showed that the gene encoding protein tyrosine kinase 7 (PTK7) is upregulated in ESCC tissues. Here, we aimed to validate PTK7 as a prognostic factor and a candidate target for molecular treatment of ESCC. Both RT-PCR and Western blot analysis of tissues from ESCC patients revealed that PTK7 was significantly upregulated in tumor tissue samples of ESCC. Immunohistochemical staining of PTK7 showed that increased expression of PTK7 was inversely correlated with overall survival (P = 0.021). In vitro knockdown of PTK7 inhibited proliferation, survival, wound healing, and invasion of ESCC cells. In addition, PTK7 knockdown decreased phosphorylation of Akt, Erk, and focal adhesion kinase (FAK), important determinants of cell proliferation, survival, and migration. Therefore, our findings suggest that PTK7 has potential as a prognostic marker for ESCC and might also be a candidate for targeted therapy in the treatment of ESCC.

Shin WS ，Kwon J ，Lee HW ，Kang MC ，Na HW ，Lee ST ，Park JH ... -  《-》

Catalytically defective receptor protein tyrosine kinase PTK7 enhances invasive phenotype by inducing MMP-9 through activation of AP-1 and NF-κB in esophageal squamous cell carcinoma cells.

Shin WS ，Hong Y ，Lee HW ，Lee ST ... -  《Oncotarget》

PTK7, a Catalytically Inactive Receptor Tyrosine Kinase, Increases Oncogenic Phenotypes in Xenograft Tumors of Esophageal Squamous Cell Carcinoma KYSE-30 Cells.

Shin WS ，Park MK ，Kim JH ，Oh SW ，Jang JY ，Lee H ，Lee ST ... -  《-》

PTK7 regulates radioresistance through nuclear factor-kappa B in esophageal squamous cell carcinoma.

Park M ，Yoon HJ ，Kang MC ，Kwon J ，Lee HW ... -  《-》

Biphasic regulation of tumorigenesis by PTK7 expression level in esophageal squamous cell carcinoma.

Shin WS ，Gim J ，Won S ，Lee ST ... -  《Scientific Reports》