The prognostic impact of human leukocyte antigen (HLA) class I antigen abnormalities in salivary gland cancer. A clinicopathological study of 288 cases.

To study abnormalities of proteins of the major histocompatibility complex class I in a series of 288 salivary gland carcinomas, and to correlate findings with patients' overall survival (OS). Protein expression of human leukocyte antigen (HLA)-A, heavy chain (HC)-10, β2 -microglobulin, low molecular weight polypeptides (LMP) 2 and 7, transporters associated with antigen processing (TAP) 1 and 2, calnexin, calreticulin, endoplasmic reticulum (ER) p57 and tapasin was evaluated by immunohistochemistry and semiquantitatively analyzed. As compared with normal salivary gland tissue, HLA-A, LMP7, TAP2 and HLA class I were significantly down-regulated in salivary gland carcinomas, whereas β2 -microglobulin, calnexin, LMP2, and TAP1 were upregulated. Expression of calreticulin, ERp57 and tapasin was unaltered. In univariate Kaplan-Meier analyses, low expression of LMP7 (P = 0.005) and high expression of β2 -microglobulin (P = 0.028), HLA-A (P < 0.001), TAP1 (P = 0.01), and tapasin (P < 0.001) were significantly associated with shorter OS. In multivariate analysis incorporating tumour stage, nodal/distant metastasis, and grade, HLA-A (P = 0.014), LMP7 (P = 0.033), and tapasin (P = 0.024), as well as distant metastasis (P = 0.012) and high tumour grade (P < 0.001), remained statistically significant. The prognostic influence of up-regulated HLA-A and tapasin and down-regulated LMP7 may provide a rationale for targeting these specific components of the antigen processing and presentation pathway in salivary gland carcinomas.

Müller M ，Agaimy A ，Zenk J ，Ettl T ，Iro H ，Hartmann A ，Seliger B ，Schwarz S ... -  《-》

Human leukocyte antigen and antigen processing machinery component defects in astrocytic tumors.

Facoetti A ，Nano R ，Zelini P ，Morbini P ，Benericetti E ，Ceroni M ，Campoli M ，Ferrone S ... -  《CLINICAL CANCER RESEARCH》

Association of antigen processing machinery and HLA class I defects with clinicopathological outcome in cervical carcinoma.

Mehta AM ，Jordanova ES ，Kenter GG ，Ferrone S ，Fleuren GJ ... -  《-》

Coordinated downregulation of the antigen presentation machinery and HLA class I/beta2-microglobulin complex is responsible for HLA-ABC loss in bladder cancer.

Romero JM ，Jiménez P ，Cabrera T ，Cózar JM ，Pedrinaci S ，Tallada M ，Garrido F ，Ruiz-Cabello F ... -  《INTERNATIONAL JOURNAL OF CANCER》

Characterization of human lymphocyte antigen class I antigen-processing machinery defects in renal cell carcinoma lesions with special emphasis on transporter-associated with antigen-processing down-regulation.

Seliger B ，Atkins D ，Bock M ，Ritz U ，Ferrone S ，Huber C ，Störkel S ... -  《CLINICAL CANCER RESEARCH》