Intestinal γδ T-cell lymphomas are most frequently of type II enteropathy-associated T-cell type.

Enteropathy-associated T-cell lymphoma includes type I cases and distinctive type II cases that, according to 2008 and 2010 World Health Organization descriptions, are T-cell receptor β+. Although T-cell receptor γδ enteropathy-associated T-cell lymphomas are reported, it is unknown if they have distinctive features and if they should be categorized as enteropathy-associated T-cell lymphoma or as a mucocutaneous γδ T-cell lymphoma. To address these questions, the clinicopathologic, immunophenotypic, molecular, and cytogenetic features of 5 γδ-enteropathy-associated T-cell lymphomas were investigated. Only 1 patient had celiac disease and had type I enteropathy-associated T-cell lymphoma, and the others fulfilled the histopathologic criteria for type II enteropathy-associated T-cell lymphoma. All lacked cutaneous involvement. A celiac disease-associated HLA type was found in the patient with CD and one of four others. All were T-cell receptor γ+, T-cell receptor δ+, βF1-, CD3+, CD7+, CD5-, CD4-, and TIA-1+ with variable staining for CD2 (3/5), CD8 (2/5), Granzyme B (1/5), and CD56 (4/5). Fluorescence in situ hybridization demonstrated 9q34 gains in 4 cases, with 9q33-34 gains by single nucleotide polymorphism in 3 of these. Single nucleotide polymorphism analysis also demonstrated gains in 5q34-q35.1/5q35.1 (4/5), 8q24 (3/5), and in 32 other regions in 3 of 5 cases. Vδ1 rearrangements were identified in 4 of 4 cases with documented clonality showing the same clone in normal-appearing distant mucosa (3/3 tested cases). Thus, γδ-enteropathy-associated T-cell lymphomas share many features with other enteropathy-associated T-cell lymphoma and are mostly of type II. Their usual nonactivated cytotoxic phenotype and Vδ1 usage are features unlike many other mucocutaneous γδ T-cell lymphomas but shared with hepatosplenic T-cell lymphoma. These findings support the conclusion that a γδ T-cell origin at extracutaneous sites does not define a specific entity.

Wilson AL ，Swerdlow SH ，Przybylski GK ，Surti U ，Choi JK ，Campo E ，Trucco MM ，Van Oss SB ，Felgar RE ... -  《-》

Genomic and immunohistochemical profiles of enteropathy-associated T-cell lymphoma in Japan.

Tomita S ，Kikuti YY ，Carreras J ，Kojima M ，Ando K ，Takasaki H ，Sakai R ，Takata K ，Yoshino T ，Bea S ，Campo E ，Nakamura N ... -  《-》

Hepatosplenic gammadelta T-cell lymphoma: ultrastructural, immunophenotypic, and functional evidence for cytotoxic T lymphocyte differentiation.

Salhany KE ，Feldman M ，Kahn MJ ，Peritt D ，Schretzenmair RD ，Wilson DM ，DiPaola RS ，Glick AD ，Kant JA ，Nowell PC ，Kamoun M ... -  《HUMAN PATHOLOGY》

Most CD56+ intestinal lymphomas are CD8+CD5-T-cell lymphomas of monomorphic small to medium size histology.

Chott A ，Haedicke W ，Mosberger I ，Födinger M ，Winkler K ，Mannhalter C ，Müller-Hermelink HK ... -  《-》

Type II enteropathy-associated T-cell lymphoma: a distinct aggressive lymphoma with frequent γδ T-cell receptor expression.

Chan JK ，Chan AC ，Cheuk W ，Wan SK ，Lee WK ，Lui YH ，Chan WK ... -  《-》