Gankyrin plays an essential role in estrogen-driven and GPR30-mediated endometrial carcinoma cell proliferation via the PTEN/PI3K/AKT signaling pathway.

Gankyrin has been implicated in the formation of multiple cancer types, although its roles in estrogen-driven endometrial carcinoma remain unclarified. We evaluated the expression of Gankyrin in endometrial tissues and further explored its roles in estrogen-driven and GPR30-mediated endometrial cancer cell proliferation. Gankyrin was overexpressed in endometrial carcinoma tissues and showed an inverse relationship with the pattern of PTEN expression. The depletion or overexpression of Gankyrin induced endometrial cancer cell proliferation inhibition or expansion, respectively, which was associated with estrogen-driven GPR30 signaling via the PTEN/PI3K/AKT pathway. This study suggests that Gankyrin is functional in endometrial cancer development.

Zhang J ，Yang Y ，Zhang Z ，He Y ，Liu Z ，Yu Y ，Wu S ，Cai B ，Feng Y ... -  《-》

The G protein-coupled receptor GPR30 mediates the nontranscriptional effect of estrogen on the activation of PI3K/Akt pathway in endometrial cancer cells.

Ge X ，Guo R ，Qiao Y ，Zhang Y ，Lei J ，Wang X ，Li L ，Hu D ... -  《-》

Nuclear estrogen receptor-mediated Notch signaling and GPR30-mediated PI3K/AKT signaling in the regulation of endometrial cancer cell proliferation.

Wei Y ，Zhang Z ，Liao H ，Wu L ，Wu X ，Zhou D ，Xi X ，Zhu Y ，Feng Y ... -  《-》

LSD1 sustains estrogen-driven endometrial carcinoma cell proliferation through the PI3K/AKT pathway via di-demethylating H3K9 of cyclin D1.

Chen C ，Wang Y ，Wang S ，Liu Y ，Zhang J ，Xu Y ，Zhang Z ，Bao W ，Wu S ... -  《-》

Gankyrin facilitates follicle-stimulating hormone-driven ovarian cancer cell proliferation through the PI3K/AKT/HIF-1α/cyclin D1 pathway.

Chen J ，Bai M ，Ning C ，Xie B ，Zhang J ，Liao H ，Xiong J ，Tao X ，Yan D ，Xi X ，Chen X ，Yu Y ，Bast RC ，Zhang Z ，Feng Y ，Zheng W ... -  《-》