T cell subsets and colorectal cancer: discerning the good from the bad.

Tumor-specific T cells must overcome a multitude of suppressive mechanisms to destroy cancerous cells effectively. Furthermore, it appears that the tumor microenvironment facilitates the development of highly immunosuppressive T cells, which may also allow subsequent tumor progression. In colorectal cancer, the relationship between regulatory T cells (e.g. FoxP3(+) Tregs) and tumor prognosis and progression is less clear, despite their well-documented ability to impinge on anti-tumor immune responses. Here we explore our current knowledge of colorectal TIL heterogeneity, deciphering subsets which may be of benefit or detriment.

Scurr M ，Gallimore A ，Godkin A 《-》

Accumulation of foxp3+ T regulatory cells in draining lymph nodes correlates with disease progression and immune suppression in colorectal cancer patients.

Deng L ，Zhang H ，Luan Y ，Zhang J ，Xing Q ，Dong S ，Wu X ，Liu M ，Wang S ... -  《-》

Identification of CD8+CD25+Foxp3+ suppressive T cells in colorectal cancer tissue.

Chaput N ，Louafi S ，Bardier A ，Charlotte F ，Vaillant JC ，Ménégaux F ，Rosenzwajg M ，Lemoine F ，Klatzmann D ，Taieb J ... -  《-》

Tumor-infiltrating FOXP3+ T regulatory cells show strong prognostic significance in colorectal cancer.

Salama P ，Phillips M ，Grieu F ，Morris M ，Zeps N ，Joseph D ，Platell C ，Iacopetta B ... -  《-》

Two FOXP3(+)CD4(+) T cell subpopulations distinctly control the prognosis of colorectal cancers.

Saito T ，Nishikawa H ，Wada H ，Nagano Y ，Sugiyama D ，Atarashi K ，Maeda Y ，Hamaguchi M ，Ohkura N ，Sato E ，Nagase H ，Nishimura J ，Yamamoto H ，Takiguchi S ，Tanoue T ，Suda W ，Morita H ，Hattori M ，Honda K ，Mori M ，Doki Y ，Sakaguchi S ... -  《-》