Relationship between depression in patients with COPD and the percent of predicted FEV(1), BODE index, and health-related quality of life.

We investigated the prevalence of depression among patients with COPD treated in long-term in-patient rehabilitation facilities, using the Center for Epidemiologic Studies Depression scale (CES-D). Furthermore, the relationship between the severity of air-flow obstruction (the percent of predicted FEV(1)), BODE (body mass index, degree of air-flow obstruction, dyspnea, exercise capacity) index, health-related quality of life (St George's Respiratory Questionnaire [SGRQ]), and depression were investigated. We recruited 74 in-patients (64 males, 10 females) with COPD. The mean age of the subjects was 72.7 years (range 52-85 y). Subjects completed the CES-D, and measurements were made of pulmonary function, body mass index, Modified Medical Research Council dyspnea scale, 6-min walk test (6MWT), and SGRQ. Depression was evident in 48.6% (n = 36) of the subjects. A weak correlation was found between the CES-D scores and the percent of predicted FEV(1). The prevalence of depression showed a significant association with BODE stage. Scores for the SGRQ activity and impacts domains, and total SGRQ score were significantly worse in the subjects who were depressed. We found a high prevalence of depression among patients with stable COPD treated in long-term in-patient rehabilitation facilities. Depression among these patients, as measured by the CES-D, was associated with greater impairment in respiratory function and with poorer Modified Medical Research Council dyspnea scale and SGRQ scores. The prevalence of depression increased with BODE stage.

Iguchi A ，Senjyu H ，Hayashi Y ，Kanada R ，Iwai S ，Honda S ，Kitagawa C ，Ozawa H ，Rikitomi N ... -  《-》

The cross-sectional and longitudinal association of the BODE index with quality of life in patients with chronic obstructive pulmonary disease.

Lin YX ，Xu WN ，Liang LR ，Pang BS ，Nie XH ，Zhang J ，Wang H ，Liu YX ，Wang DQ ，Xu ZY ，Wang HW ，Zhang HS ，He ZY ，Yang T ，Wang C ... -  《-》

Depression and its relationship with poor exercise capacity, BODE index and muscle wasting in COPD.

Al-shair K ，Dockry R ，Mallia-Milanes B ，Kolsum U ，Singh D ，Vestbo J ... -  《-》

Health-related quality of life is associated with COPD severity: a comparison between the GOLD staging and the BODE index.

Medinas Amorós M ，Mas-Tous C ，Renom-Sotorra F ，Rubí-Ponseti M ，Centeno-Flores MJ ，Gorriz-Dolz MT ... -  《Chronic Respiratory Disease》

Behavior of Quality of Life (SGRQ) in COPD Patients According to BODE Scores.

To evaluate if the association between the BODE index and deterioration in health-related quality of life is linear. To determine possible associations between the BODE index and health status evaluated by the Saint George's Respiratory Questionnaire (SGRQ) at all levels of disease severity in COPD. A cross-sectional study was carried out on 253 patients from two Latin American respiratory centers (Brazil and Chile) with a clinical diagnosis of COPD, based on GOLD criteria. Assessment included the BODE index and the SGRQ questionnaire. Patients had a BODE index of 3.1±2.0; FEV1 (%) of 49±19.2; BMI (kg/m(2)) of 24.7±5.1; 6MWT distance (meters) of 444±96. Significant correlations were found between the BODE index and SGRQ total scores (r=0.5; <0.001), impact (r=0.45; <0.001) and activity (r=0.5; <0.001). From BODE score zero, HRQOL was already compromised in all SGRQ domains. SGRQ scores (total and domain) increased progressively for individual components of the BODE index, with the decrease in airflow limitation (<0.05), BMI (<0.002) and 6MWT (<0.05), and with the increase in the Modified Medical Research Council (MMRC) score (<0.05). There is an association between health-related quality of life, as assessed by the SGRQ and the BODE index within the entire spectrum of COPD severity. Even in early disease stages and BODE index zero, health-related quality of life is already impaired.

Nonato NL ，Díaz O ，Nascimento OA ，Dreyse J ，Jardim JR ，Lisboa C ... -  《-》