Syndecan-1 (CD 138) surface expression marks cell type and differentiation in ameloblastoma, keratocystic odontogenic tumor, and dentigerous cyst.

The altered expression of syndecan-1 (SD-1), a transmembrane heparan sulfate proteoglycan, in ameloblastomas and cysts of odontogenic origin suggests that this molecule could have prognostic value in assessing the clinical outcome of those lesions. The purpose of this study was to analyze SD-1 expression profile immunohistochemically in archival, paraffin-embedded tissue sections of ameloblastomas and in common odontogenic cysts arising from the same locale. SD-1 expression was investigated in 32 ameloblastomas, 26 keratocystic odontogenic tumors (KCOT), and 21 dentigerous cysts from the archives of the histopathology laboratory which were routinely processed. The cases were reviewed and assessed according to the established criteria. Sections were immunostained with monoclonal antibody against SD-1 (CD138). Sections of normal oral mucosa, site matched, were stained in parallel as positive controls. The plasma cells in sections served as internal positive controls. SD-1 expression was observed in the epithelial and stromal elements of the sections, and the expression was significantly associated with the lesion's extension and involvement of adjacent structures (P=0.025). Stellate-reticulum cells showed higher expression than the ameloblasts, which was at a significant level (P<0.0001). Highly significant difference was reported among the three groups of lesion for the epithelial staining (P<0.0001). The mean rank scores (Kruskal-Wallis test) of ameloblastomas were significantly lower than those of KCOT and dentigerous cysts. Non-significant comparison was made between KCOT and dentigerous cyst groups. The present study revealed SD-1 immunoreactivity in the stromal cells of ameloblastoma, KCOT, and dentigerous cysts rather uniformly. This reported SD-1 expression by the tumor stroma is considered to be associated with poor prognosis of the lesions.

Al-Otaibi O ，Khounganian R ，Anil S ，Rajendran R ... -  《-》

Significance of podoplanin expression in keratocystic odontogenic tumor.

Okamoto E ，Kikuchi K ，Miyazaki Y ，González-Alva P ，Oku Y ，Tanaka A ，Yoshida N ，Fujinami M ，Ide F ，Sakashita H ，Kusama K ... -  《-》

Comparative expression of RANK, RANKL, and OPG in keratocystic odontogenic tumors, ameloblastomas, and dentigerous cysts.

da Silva TA ，Batista AC ，Mendonça EF ，Leles CR ，Fukada S ，Cunha FQ ... -  《-》

CD1a-positive Langerhans cells and their relationship with E-cadherin in ameloblastomas and keratocystic odontogenic tumors.

Ameloblastomas and keratocystic odontogenic tumors (KOTs) are lesions that are characterized by locally invasive growth and cause extensive bone destruction. In addition, it is known that E-cadherin influences the adhesion of Langerhans cells (LCs) to keratinocytes. The aim of this study was to investigate, using immunohistochemistry, the distribution of CD1a-positive cells in ameloblastomas and KOTs and their relationship with E-cadherin, in comparison to calcifying cystic odontogenic tumor (CCOT). The CD1a-positive LCs were observed in 11 ameloblastomas and KOTs. All of the cases of CCOT showed CD1a-positive LCs and a significant difference was found when this tumor was compared with ameloblastomas (P < 0.05, Mann-Whitney test). A statistically significant difference was also noted when comparing CD1a-positive LCs between CCOTs and KOTs (P < 0.05, Mann-Whitney test). Lower expression of E-cadherin in ameloblastomas (AMs) in relation to KOTs and CCOTs (P < 0.05, Fisher test) was observed. There was no correlation between E-cadherin and CD1a-positive LCs between all odontogenic tumors that were studied (P > 0.05, Spearman test). A quantitative difference of CD1a-positive cells between AMs and KOTs in comparison to CCOTs was observed. This permits to speculate that a depletion of CD1a-positive LCs might influence the local invasiveness of ameloblastomas and KOTs. Furthermore, it is suggested that E-cadherin mediates cell adhesion in these tumors.

Mello LA ，Figueiredo AL ，Ramos EA ，Gurgel CA ，Martins MD ，de Figueiredo CR ，Cury PR ，de Albuquerque Júnior RL ，Ramalho LM ，Santos JN ... -  《-》

Immunohistochemical characteristics of cystic odontogenic lesions: a comparative study.

Özcan A ，Yavan İ ，Günhan Ö 《-》