Determinants of informed consent in a cataract surgery clinical trial: why patients participate.

To identify the determinants of patients' decision-making for participation in a cataract surgery clinical trial in a tertiary care hospital. Prospective observational study. We interviewed by questionnaire 40 patients scheduled to have cataract surgery. The data collected from patients included attitudes about informed consent, evaluation of the provision of information, and sociodemographic variables. Overall, 20 (50%) patients consented to enter the trial. All patients (n = 20;100%) in the consenting group expected positive implications compared to 6 (30%) in the nonconsenting group, who expected negative implications (p = 0.008). The majority of patients (90%) in the nonconsenting group felt that the degree of risk incurred by undergoing trial treatment was moderate to high. The perceived burden imposed on daily life by participating was seen by the nonconsenting group to be moderately higher in 11 patients (55%) compared to 3 patients (15%) in the consenting group (p = 0.026). Of the nonconsenting patients, 50% were dissatisfied with the attitudes of medical experiments as compared to 2% of those who did consent (p = 0.023). The major reasons for participation in a cataract surgery trial were (i) expected positive implications resulting from involvement; and (ii) satisfaction with the attitudes of medical experiments. Patients who refused to enter the trial felt that the degree of risk as well as the burden imposed on daily life by participating were high. Demographic variables did not have any impact on a patients' decisions to accept or decline entry into the trial.

Constantinou M ，Jhanji V ，Chiang PP ，Lamoureux EL ，Rees G ，Vajpayee RB ... -  《-》

Understanding the decisions of cancer clinical trial participants to enter research studies: factors associated with informed consent, patient satisfaction, and decisional regret.

Stryker JE ，Wray RJ ，Emmons KM ，Winer E ，Demetri G ... -  《PATIENT EDUCATION AND COUNSELING》

Informed consent and decision making by cataract patients.

Kiss CG ，Richter-Mueksch S ，Stifter E ，Diendorfer-Radner G ，Velikay-Parel M ，Radner W ... -  《archives of ophthalmology》

Patients' motives for consenting or refusing to participate in a clinical trial in organ transplantation.

The goal of this health-psychology study was to investigate the range of motives that make someone consent or refuse participation in a clinical transplant trial. The study involved (i) preparatory interviews with five transplant patients who took part in clinical trials and five persons from the general public; (ii) we created a questionnaire with scaled responses; (iii) we selected 468 patients, divided into two groups: patients waiting for a transplant and patients who already had a transplant; (iv) we obtained patient consents, sent out the questionnaire, and recorded responses; (v) data were analysed using descriptive statistics, exploratory factorial analyses, correlations and regressions. Two hundred and ten patients answered the questionnaire. Motives were classified into the following: (i) Motives to consent participating in a clinical trial (pride in participating, hope for better quality of life, sufficient and clear information, discussion with others participating in a trial, altruism); or (ii) Motives to refuse participating (no information on medical teams, lack of explanation, fear of additional expenses, being considered a "guinea pig"). This study contributes to our understanding of the motivations of patients who accepted or refused participation in a clinical transplantation trial.

Guedj M ，Ballester S ，Kamar N ，Rostaing L ，Donckier V ，Goldman M ，Cambon-Thomsen A ... -  《-》

Discussing resident participation in cataract surgery.

Gan KD ，Rudnisky CJ ，Weis E 《-》