Magnetic resonance cholangiography in living donor liver transplantation: comparison of preenhanced and post-gadolinium-enhanced methods.

The purpose of this study was to evaluate the image quality and diagnostic accuracy of postgadolinium complex of diethylenetriaminepentaacetic acid (GD-DTPA)-enhanced magnetic resonance cholangiography (MRC) in donor selection. Donors (n=228) with both preoperative MRC and intraoperative cholangiography (IOC) were enrolled in this study. MRC pre- and post-GD-DTPA enhancement were performed using 1.5-T magnetic resonance imaging. The signal-to-noise ratio (SNR) of liver parenchyma and contrast-to-noise ratio of bile duct, as well as the contrast between bile duct and liver parenchyma, were calculated. The biliary anatomy correlation with the IOC during hepatectomy and patient prognosis were also evaluated. Quantitative results of the SNR of the liver parenchyma post-GD-DTPA were statistically significantly lower than preenhanced MRC (2.69 times reduced from the preenhanced MRC). The contrast of the bile duct and liver parenchyma in post-GD-DTPA were significantly higher than the preenhancement MRC. The anatomic diagnostic accuracy rate of post-GD-DTPA MRC was 92.9%. The sensitivity and specificity of GD-PTPA MRC were 85% and 96%, respectively. GD-DTPA-enhanced MRC has higher accuracy than the preenhanced MRC (92.9% vs 75%). The concurrence between GD-DTPA-enhanced MRC and IOC were commendable (kappa=0.9). The posttransplant biliary complication rate was 5.5%, and the 3-year survival rate was 91.2% in the recipients. GD-DTPA, a paramagnetic metal, can shorten the T1 and T2 relaxation values of surrounding protons. This decreases the signal of the liver parenchyma and brightens the biliary anatomy. It can improve the image quality of MRC and increase the diagnostic accuracy of the biliary tract classification. It is mandatory in the "donor and recipient surgery during the LDLT".

Chiang HJ ，Hsu HW ，Chen PC ，Chiang HW ，Huang TL ，Chen TY ，Chen CL ，Cheng YF ... -  《-》

The efficiency of Gd-EOB-DTPA-enhanced magnetic resonance cholangiography in living donor liver transplantation: a preliminary study.

The aim of this study was to evaluate utility of gadoxetic acid disodium (Gd-EOB-DTPA)-enhanced magnetic resonance cholangiography (MRC) for the detection of biliary complications after living donor liver transplantation (LDLT). A total of 18 patients with suspected biliary complications underwent MRC. T2-weighted MRC and contrast-enhanced MRC (CE-MRC) were used to identify the biliary complications. MRC included routine breath-hold T2-weighted MRC using half-Fourier acquisition single-shot turbo spin-echo (HASTE) sequences and Gd-EOB-DTPA-enhanced MRC T1-weighted volumetric interpolated breath-hold examination (VIBE) sequences. Before confirming the biliary complications, one observer reviewed the MRC images and the CE-MRC images separately. The verification procedures and MRC findings were compared, and the sensitivity, specificity, and accuracy of both techniques were calculated for the identification of biliary complications. The observer found six of seven biliary complications using CE-MRC. The sensitivity was 85.7% and the accuracy was 94.4%. Using MRC alone, sensitivity was 57.1% and accuracy was 55.5%. The accuracy of Gd-EOB-DTPA-enhanced MRC was superior to MRC in locating biliary leaks (p < 0.05). The usage of Gd-EOB-DTPA-enhanced MRC yields information that complements the MRC findings that improve the identification of biliary complications. We recommend the use of MRC in addition to Gd-EOB-DTPA-enhanced MRC to increase the preoperative accuracy when assessing the biliary complications after LDLT.

Ogul H ，Kantarci M ，Pirimoglu B ，Karaca L ，Aydinli B ，Okur A ，Ozturk G ，Kizrak Y ... -  《-》

Bile duct evaluation of potential living liver donors with Gd-EOB-DTPA enhanced MR cholangiography: Single-dose, double dose or half-dose contrast enhanced imaging.

Detailed knowledge of the biliary anatomy is essential to avoid complications in living donor liver transplantation. The aim of this study was to determine the optimal dosage of Gd-EOB-DTPA for contrast-enhanced magnetic resonance cholangiography (ce-MRC) with reference to contrast-enhanced CT cholangiography (ce-CTC). 30 potential living liver donors (PLLD) underwent both ce-CTC and ce-MRC. Ten candidates each received single, double or half-dose Gd-EOB-DTPA. Ce-MRC images with and without inversion recovery pulses (T1w±IR) were acquired 20-30min after intravenous contrast injection. Image data was quantitatively and qualitatively reviewed by two radiologists based on a on a 5-point scale. Data sets were compared using a Mann-Whitney-U-test or Wilcoxon-rank-sum-test. Kappa values were also calculated. All image series provided sufficient diagnostic information both showing normal biliary anatomy and variant bile ducts. Ce-CTC showed statistically significant better results compared to all ce-MRC data sets. T1w MRC with single dose Gd-EOB-DTPA proved to be superior to half and double dose in subjective and objective evaluation without a statistically significant difference. Ce-MRC is at any dosage inferior to ce-CTC. As far as preoperative planning of bile duct surgery is focused on the central biliary anatomy, ce-MRC can replace harmful ce-CTC strategies, anyway. Best results were seen with single dose GD-EOB-DTPA on T1w MRC+IR.

Kinner S ，Steinweg V ，Maderwald S ，Radtke A ，Sotiropoulos G ，Forsting M ，Schroeder T ... -  《-》

Contrast-enhanced MR cholangiography with Gd-EOB-DTPA for preoperative biliary mapping: correlation with intraoperative cholangiography.

Gd-EOB-DTPA-enhanced magnetic resonance (MR) could be used for preoperative evaluation of bile duct anatomy in addition to conventional information of focal hepatic lesions. To evaluate accuracy of contrast-enhanced MR cholangiography (CE MRC) reconstructed from Gd-EOB-DTPA-enhanced MR images for depicting biliary anatomy with intraoperative cholangiography. We retrospectively identified 71 patients who underwent both preoperative Gd-EOB-DTPA-enhanced MR imaging (MRI) and intraoperative cholangiography for hepatic resections. Two readers independently analyzed biliary anatomy using CE MRC reconstructed from transverse and coronal images separately in 4 weeks. The accuracy and diagnostic confidence were evaluated in correlation with intraoperative cholangiography. The accuracy and confidence score (3-point scale) were compared on CE MRCs from transverse versus coronal images. CE MRCs correctly depicted biliary anatomy in 91.5% and 88.7% with coronal images and in 81.7% and 73.2% with transverse images for readers 1 and 2, respectively. CE MRCs from coronal images tended to show greater accuracy (P = 0.12 and 0.01, for readers 1 and 2) and higher confidence score (P = 0.11 and P = 0.04, for readers 1 and 2) than those from transverse images. Accurate preoperative biliary mapping can be achieved on CE MRC reconstructed from Gd-EOB-DTPA-enhanced MR images. The diagnostic performance was better on CE MRC reconstructed from coronal than those from transverse images.

Lee Y ，Kim SY ，Kim KW ，Lee SS ，Park SH ，Byun JH ，Lee MG ... -  《-》

Preoperative evaluation of biliary anatomy in adult live liver donors with volumetric mangafodipir trisodium enhanced magnetic resonance cholangiography.

Ayuso JR ，Ayuso C ，Bombuy E ，De Juan C ，Llovet JM ，De Caralt TM ，Sánchez M ，Pagés M ，Bruix J ，García-Valdecasas JC ... -  《LIVER TRANSPLANTATION》