Breast cancer resistance protein expression is associated with early recurrence and decreased survival in resectable pancreatic cancer patients.

The prognosis of pancreatic ductal adenocarcinoma (PDAC) remains dismal even after complete resection, with most recurrences occurring within 1-2 years postoperatively. Adenosine triphosphate (ATP)-binding cassette (ABC) transporters have been demonstrated to play major roles in multidrug resistance (MDR) of cancers. In this study, we evaluated the expression statuses and the clinical significance of MDR1 (ABCB1), MDR-associated proteins (MRPs/ABCC) 1, 2 and 3, and breast cancer resistance protein (BCRP/ABCG2) in 67 surgically resected PDACs by immunohistochemistry. MDR1, MRP1, MRP2, MRP3 and BCRP were expressed in 35 (52.2%), 56 (83.6%), 61 (91.0%), 49 (73.1%) and 49 (73.1%) out of 67 cases, respectively. The expression statuses of the MDR-related proteins were positively correlated with each other (P < 0.05). Tumors expressing MRP1 (P= 0.015), MRP2 (P= 0.022) and MRP3 (P < 0.001) demonstrated more frequent perineural invasion. MDR1 expression was significantly correlated with lymphatic invasion (P= 0.047). High BCRP expression in PDAC was a significant prognostic factor for early tumor recurrence (HR = 2.43, P= 0.003) and poor survival (HR = 2.63, P= 0.001). MDR-related proteins are frequently expressed in PDAC, and high BCRP expression is a significant independent predictor for early recurrence and poor survival. Immunohistochemical analysis for BCRP expression in PDAC may be a useful test in identifying a subgroup of patients with a poor prognosis.

Lee SH ，Kim H ，Hwang JH ，Lee HS ，Cho JY ，Yoon YS ，Han HS ... -  《-》

Expression and promoter methylation analysis of ATP-binding cassette genes in pancreatic cancer.

Chen M ，Xue X ，Wang F ，An Y ，Tang D ，Xu Y ，Wang H ，Yuan Z ，Gao W ，Wei J ，Zhang J ，Miao Y ... -  《-》

The clinical significance of FRAT1 and ABCG2 expression in pancreatic ductal adenocarcinoma.

Yuan Y ，Yang Z ，Miao X ，Li D ，Liu Z ，Zou Q ... -  《-》

RNA expression of breast cancer resistance protein, lung resistance-related protein, multidrug resistance-associated proteins 1 and 2, and multidrug resistance gene 1 in breast cancer: correlation with chemotherapeutic response.

Burger H ，Foekens JA ，Look MP ，Meijer-van Gelder ME ，Klijn JG ，Wiemer EA ，Stoter G ，Nooter K ... -  《CLINICAL CANCER RESEARCH》

The roles of four multi-drug resistance proteins in hepatocellular carcinoma multidrug resistance.

Li G ，Chen X ，Wang Q ，Xu Z ，Zhang W ，Ye L ... -  《Journal of Huazhong University of Science and Technology-Medical Sciences》