Orthostatic hypotension (OH) and mortality in relation to age, blood pressure and frailty.

Systolic hypertension and OH, as with many other deficits, accumulate with age. This deficit accumulation results in frailty: enhanced vulnerability to adverse outcomes. This study evaluated OH in relation to age, frailty, systolic hypertension, and mortality. In the population-based Canadian Study of Health and Aging second clinical examination, complete data were available on 1347 people, mean age=83.3 (SD=6.4)years. A frailty index (FI) was calculated from a 52-item Comprehensive Geriatric Assessment (CGA), yielding an FI-CGA from 0 (no deficits) to 1.0 (52 deficits). The mean change in blood pressure from lying to standing was 7.3±15.6 mmHg (range +94 to -60). In total, 239 people (17.7%) had OH (change >20 mmHg systolic or >10 mmHg diastolic). Mean systolic blood pressure was higher (155.8±23.3 mmHg) in people with OH than in those without (141.4±23 mmHg), as was the FI-CGA (0.18 vs. 0.16). OH increased with frailty and systolic hypertension, but not age. Unadjusted, OH was associated with an increased risk of death (relative risk=1.21, 95% confidence interval 1.19-1.23). Adjusted for frailty, this result was not significant. OH may be a marker of the system dysregulation seen in frailty, but as a state variable is a less powerful marker of vulnerability than is the FI-CGA.

Rockwood MR ，Howlett SE ，Rockwood K 《-》

Physiological redundancy in older adults in relation to the change with age in the slope of a frailty index.

Rockwood K ，Rockwood MR ，Mitnitski A 《-》

Relationships between orthostatic hypotension, frailty, falling and mortality in elderly care home residents.

Shaw BH ，Borrel D ，Sabbaghan K ，Kum C ，Yang Y ，Robinovitch SN ，Claydon VE ... -  《BMC Geriatrics》

Prevalence and 10-year outcomes of frailty in older adults in relation to deficit accumulation.

Song X ，Mitnitski A ，Rockwood K 《-》

The risk of adverse outcomes in hospitalized older patients in relation to a frailty index based on a comprehensive geriatric assessment.

Evans SJ ，Sayers M ，Mitnitski A ，Rockwood K ... -  《-》