Bam and Bgcn in Drosophila germline stem cell differentiation.

The female Drosophila reproductive organ, the ovary, has provided researchers with an incisive genetic system with which principle regulation of stem cell maintenance and differentiation has been delineated. An environmental niche regulates a stem cell's asymmetric self-renewal division that produces a daughter stem cell and a differentiated daughter cell, which further differentiate into eggs. A number of extrinsic and intrinsic factors have been identified that are required either for stem cell maintenance or differentiation. Bam/Bgcn complex plays a pivotal role in promoting stem cell differentiation. Recent papers suggest that Bam/Bgcn complex regulates translation of important maintenance factors and is also involved in the regulation of microRNA-dependent translational repression. Here, we focus on Bam and Bgcn repression of stem cell maintenance factors in the differentiation of germline stem cells (GSCs).

Perinthottathil S ，Kim C 《Vitamins and Hormones》

Histone H3K9 trimethylase Eggless controls germline stem cell maintenance and differentiation.

Wang X ，Pan L ，Wang S ，Zhou J ，McDowell W ，Park J ，Haug J ，Staehling K ，Tang H ，Xie T ... -  《PLoS Genetics》

Bam and Bgcn antagonize Nanos-dependent germ-line stem cell maintenance.

Li Y ，Minor NT ，Park JK ，McKearin DM ，Maines JZ ... -  《-》

Direct inhibition of Pumilo activity by Bam and Bgcn in Drosophila germ line stem cell differentiation.

Kim JY ，Lee YC ，Kim C 《-》

Three RNA binding proteins form a complex to promote differentiation of germline stem cell lineage in Drosophila.

Chen D ，Wu C ，Zhao S ，Geng Q ，Gao Y ，Li X ，Zhang Y ，Wang Z ... -  《PLoS Genetics》