[Lymphomatoid granulomatosis revealed by cutaneous lesions].

Lymphomatoid granulomatosis is a rare Epstein Barr virus (EBV)-related lymphoproliferative disorder. It most frequently involves the lungs, skin and central nervous system and arises preferentially in patients with immune disorders. Here we report a case revealed by cutaneous lesions in an immunocompetent patient. A 56-year-old man consulted for erythematous nodules of the trunk associated with malaise and marked weight loss (14kg). In a few days the nodules became necrotic. Two weeks later a cough appeared and the chest computerized tomography showed multiple poorly defined nodular opacities with a peribronchovascular distribution. Cutaneous and pulmonary biopsies showed an infiltrate composed of medium-sized atypical lymphocytes T and B. EBV was present in the infiltrate (in situ hybridization) with a high EBV load in plasma. All of these data helped confirm the diagnosis of lymphoid granulomatosis. Despite aggressive treatment with polychemotherapy, the patient died after 2 months. Lymphomatoid granulomatosis represents a diagnostic challenge. In most cases, the presenting symptoms are not specific: malaise, weight loss, fever and cough. Moreover histology is difficult because of the T-cell-rich background. It is essential to consider this diagnosis in cases of cutaneous and pulmonary symptoms.

Quéreux G ，Brocard A ，Peuvrel L ，Knol AC ，Renaut JJ ，Dréno B ... -  《ANNALES DE DERMATOLOGIE ET DE VENEREOLOGIE》

[Primary and isolated cutaneous lymphomatoid granulomatosis following heart-lung transplantation].

Tas S ，Simonart T ，Dargent J ，Kentos A ，Antoine M ，Knoop C ，Estenne M ，De Dobbeleer G ... -  《-》

Association of lymphomatoid granulomatosis with Epstein-Barr viral infection of B lymphocytes and response to interferon-alpha 2b.

Wilson WH ，Kingma DW ，Raffeld M ，Wittes RE ，Jaffe ES ... -  《-》

Lymphomatoid granulomatosis of the skin and lung. An angiocentric T-cell-rich B-cell lymphoproliferative disorder.

McNiff JM ，Cooper D ，Howe G ，Crotty PL ，Tallini G ，Crouch J ，Eisen RN ... -  《ARCHIVES OF DERMATOLOGY》

Failure of CHOP with rituximab for lymphomatoid granulomatosis.

Oosting-Lenstra SF ，van Marwijk Kooy M 《-》