The role of CD10 in distinguishing atypical fibroxanthoma from sarcomatoid (spindle cell) squamous cell carcinoma.

The role of CD10 needs clarification in a broader immunohistochemical battery for distinguishing atypical fibroxanthoma (AFX) from spindle cell squamous cell carcinoma (sSCC). We retrospectively reviewed 23 cutaneous spindle cell tumors previously classified as AFX (n = 11) or as sSCC (n = 12). Each tumor was stained with CD10, S-100, p63 and two or more cytokeratin stains. Defining AFX as a diagnosis of exclusion based on multiple negative cytokeratin stains and negative p63 staining, we reclassified four squamous cell carcinomas (SCCs) as AFX. CD10 staining was reviewed and graded in all tumors. Fifteen tumors were classified as AFX. Strongly positive CD10 staining was observed in all 15 AFXs, as well as four (50%) of the eight SCCs. Expression of p63 was seen in six sSCCs (75%). CD10 is consistently expressed by AFX. However, CD10 is also often strongly expressed by sSCC. Positive staining with p63 favors a diagnosis of sSCC. An immunohistochemical battery useful for distinguishing AFX from sSCC may include CD10, p63 and two cytokeratin markers. However, CD10 alone should not be relied upon in the distinction of these entities.

Wieland CN ，Dyck R ，Weenig RH ，Comfere NI ... -  《-》

Role of CD10, wide-spectrum keratin, p63, and podoplanin in the distinction of epithelioid and spindle cell tumors of the skin: an immunohistochemical study of 81 cases.

Buonaccorsi JN ，Plaza JA 《-》

Utility of p63 in the differential diagnosis of atypical fibroxanthoma and spindle cell squamous cell carcinoma.

Gleason BC ，Calder KB ，Cibull TL ，Thomas AB ，Billings SD ，Morgan MB ，Hiatt KM ，Smoller BR ... -  《-》

Immunohistochemical staining of CD10 in atypical fibroxanthomas.

Hultgren TL ，DiMaio DJ 《JOURNAL OF CUTANEOUS PATHOLOGY》

Evaluation of CD10 and procollagen 1 expression in atypical fibroxanthoma and dermatofibroma.

de Feraudy S ，Mar N ，McCalmont TH 《-》