Idiopathic inflammatory myopathies in childhood: a brief review of 27 cases.

The most common idiopathic inflammatory myopathies in children include juvenile dermatomyositis, juvenile polymyositis, and myositis associated with another autoimmune disease (overlap myositis). Idiopathic inflammatory myopathies manifest different characteristics affecting children. Only a few investigations of childhood idiopathic inflammatory myopathies were reported, involving 27 patients. In addition, clinical findings, serum muscular enzyme levels, results of electromyography studies, muscle biopsy features, and treatment responses were studied. Seventeen female and 10 male were classified as exhibiting juvenile dermatomyositis (n = 19), juvenile polymyositis (n = 6), or overlap myositis (n = 2). Overlap myositis was associated with systemic sclerosis and systemic erythematous lupus. The mean age at onset was 6.1 years for juvenile dermatomyositis, 4.9 years for juvenile polymyositis, and 8.5 years for overlap myositis. The most common signs included proximal weakness and myalgia. The serum creatine kinase level was increased in 48.2% of patients. An electromyography study revealed myopathic features in 85% of patients. Muscle biopsies led to observations of inflammatory infiltrates with preferential perivascular involvement in the juvenile dermatomyositis group, and endomysial involvement in the juvenile polymyositis group. Fiber atrophy was predominantly perifascicular in the juvenile dermatomyositis group. Treatment with prednisone improved the findings in 81.5% of children.

Lorenzoni PJ ，Scola RH ，Kay CS ，Prevedello PG ，Espíndola G ，Werneck LC ... -  《-》

Clinical spectrum of inflammatory myositis in South India--a ten year study.

Porkodi R ，Shanmuganandan K ，Parthiban M ，Madhavan R ，Rajendran P ... -  《-》

Inflammatory myopathies: evaluation and management.

Greenberg SA 《SEMINARS IN NEUROLOGY》

Development of validated disease activity and damage indices for the juvenile idiopathic inflammatory myopathies. II. The Childhood Myositis Assessment Scale (CMAS): a quantitative tool for the evaluation of muscle function. The Juvenile Dermatomyositis D

Lovell DJ ，Lindsley CB ，Rennebohm RM ，Ballinger SH ，Bowyer SL ，Giannini EH ，Hicks JE ，Levinson JE ，Mier R ，Pachman LM ，Passo MH ，Perez MD ，Reed AM ，Schikler KN ，Smith M ，Zemel LS ，Rider LG ... -  《-》

[Dermatomyositis and polymyositis: clinical aspects and treatment].

Hachulla E 《-》