Immunogenicity of a combination vaccine containing diphtheria toxoid, tetanus toxoid, three-component acellular pertussis, hepatitis B, inactivated polio virus, and Haemophilus influenzae type b when given concomitantly with 13-valent pneumococcal conjuga

Two randomized trials of 13-valent pneumococcal conjugate vaccine (PCV13) relative to PCV7 evaluated the immune responses of coadministered antigens comprising Infanrix(®) hexa/Infanrix(®)-IPV+Hib (diphtheria, tetanus, 3-component acellular pertussis, hepatitis B, inactivated poliovirus, and Haemophilus influenzae type b). After the 3-dose infant series, immunogenic noninferiority was demonstrated for all concomitantly administered antigens between the PCV13 and PCV7 groups. All antigens elicited good booster responses after the toddler dose except pertussis toxoid; however, 99.6% subjects achieved pertussis toxoid protective antibody level ≥5EU/mL in both groups. These results support the concomitant administration of PCV13 and Infanrix hexa/Infanrix-IPV+Hib as part of routine immunization schedules.

Gimenez-Sanchez F ，Kieninger DM ，Kueper K ，Martinon-Torres F ，Bernaola E ，Diez-Domingo J ，Steul K ，Juergens C ，Gurtman A ，Giardina P ，Liang JZ ，Gruber WC ，Emini EA ，Scott DA ，501 and 006 study groups ... -  《-》

Safety and immunogenicity of a toddler dose following an infant series of a hexavalent diphtheria, tetanus, acellular pertussis, inactivated poliovirus, Haemophilus influenzae type b, hepatitis B vaccine administered concurrently or at separate visits wit

Halperin SA ，Tapiéro B ，Dionne M ，Meekison W ，Diaz-Mitoma F ，Zickler P ，Rubin E ，Embree J ，Bhuyan P ，Lee A ，Li M ，Tomovici A ... -  《-》

13-valent pneumococcal conjugate vaccine given with meningococcal C-tetanus toxoid conjugate and other routine pediatric vaccinations: immunogenicity and safety.

Martinón-Torres F ，Gimenez-Sanchez F ，Gurtman A ，Bernaola E ，Diez-Domingo J ，Carmona A ，Sidhu M ，Sarkozy DA ，Gruber WC ，Emini EA ，Scott DA ，3007 Study Group ... -  《-》

Immunogenicity, reactogenicity and safety of a 7-valent pneumococcal conjugate vaccine (PCV7) concurrently administered with a DTPa-HBV-IPV/Hib combination vaccine in healthy infants.

Knuf M ，Habermehl P ，Cimino C ，Petersen G ，Schmitt HJ ... -  《VACCINE》

Immunogenicity and safety of a combination diphtheria, tetanus toxoid, acellular pertussis, hepatitis B, and inactivated poliovirus vaccine coadministered with a 7-valent pneumococcal conjugate vaccine and a Haemophilus influenzae type b conjugate vaccine

Pichichero ME ，Bernstein H ，Blatter MM ，Schuerman L ，Cheuvart B ，Holmes SJ ，085 Study Investigators ... -  《-》