Clinical validation of the EORTC QLQ-OG25 questionnaire for the evaluation of health-related quality of life in Mexican patients with esophagogastric cancers.

Quality of life questionnaires (QLQ) QLQ-STO22 and QLQ-OES18 are currently available to measure Health-related quality of life (HRQL) in patients with Esophageal (EC) or Gastric cancer (GC). The QLQ-OG25 integrates questions from both questionnaires to be useful for EC, Esophagogastric junction carcinoma (EGJC), and GC. Our aim was to validate the Mexican-Spanish version. The translation procedure followed European Organization for Research and Treatment of Cancer (EORTC) guidelines. QLQ-C30 and QLQ-OG25 instruments were completed by patients with EC, EGJC, and GC. Patients were divided into three groups: (1) palliative treatment; (2) treatment with curative intent, and (3) survivors. Reliability and validity tests were performed. One-hundred sixty-three patients were included: 62 women and 101 men (mean age, 54.9 years; range, 22-82 years). Sixty-nine, seventy-three, and twenty-one patients were allocated into groups 1, 2, and 3, respectively. Questionnaire compliance rates were high and were well accepted. Group 3 patients reported better functional HRQL scores and lower symptom scores than patients in groups 2 and 1. Scales in the QLQ-C30 and QLQ-OG25 distinguished among other clinically distinct groups of patients. Cronbach's α coefficients of all multi-item scales of the QLQ-OG25 instrument were >0.7 (range, 0.7-0.83). Multitrait scaling analysis demonstrated good convergent and discriminant validity, even adjusting by location. Test-retest scores were consistent. The Mexican-Spanish version of the EORTC QLQ-OG25 questionnaire is reliable and valid for HRQL measurement in patients with esophagogastric cancer and can be used in clinical trials in the Mexican community.

Oñate-Ocaña LF ，Velázquez-Monroy N ，Vázquez L ，Espinosa-Mireles-de-Villafranca P ，Núñez-Rosas E ，Ovando-Lezama M ，Vilar-Compte D ，García-Hubard G ，Carrillo JF ，Blazeby JM ，Aiello-Crocifoglio V ... -  《-》

Validation of the Mexican Spanish version of the EORTC C30 and STO22 questionnaires for the evaluation of health-related quality of life in patients with gastric cancer.

Oñate-Ocaña LF ，Alcántara-Pilar A ，Vilar-Compte D ，García-Hubard G ，Rojas-Castillo E ，Alvarado-Aguilar S ，Carrillo JF ，Blazeby JM ，Aiello-Crocifoglio V ... -  《-》

Psychometric analysis of a Persian version of the European Organization for Research and Treatment of Cancer OG25 Quality of Life Questionnaire in oesophagogastric cancer patients.

Hesari AE ，Lari MA ，Shandiz FH 《-》

Validity and Reliability of the Amharic Version of EORTC QLQ-OG25 Among Esophagogastric Cancer Patients in Ethiopia.

Cancers of the stomach and esophagus are the fourth and sixth most common causes of cancer-related deaths worldwide, respectively. Although various tools have been developed to assess the quality of life of patients with esophagogastric cancer, EORTC QLQ-C30 and EORTC QLQ-OG25 are the most used all over the world. However, they have not been validated in an Ethiopian context. Therefore, this study aimed to evaluate the psychometric properties of EORTC QLQ-OG25 among Ethiopian patients with esophageal and gastric cancer. EORTC QLQ-OG25 is a 25-item tool with 10 single items and six symptom scales: Eating restrictions, reflux, dysphagia, odynophagia, discomfort and pain, and anxiety. The tool was translated into Amharic according to the EORTC forward-backward translation protocol. To check its validity and reliability, a cross-sectional study among 158 patients was conducted from March to May 2020 at Tikur Anbessa Specialized Hospital, Addis Ababa, Ethiopia. The psychometric properties of EORTC QLQ-C30 and EORTC QLQ-OG25 were assessed using multitrait scale analysis, known group validity, convergent validity, and divergent validity. Internal consistency was examined with Cronbach's alpha. Eighty-three (52.5%) of the participants were men; the median age was 50 years (IQR = 18 years). The overall item correlation alpha values ranged between 0.39 and 0.7. All item correlations within their scales were greater than 0.4. The correlation coefficients between all items and their own domain were greater than for other domains. The esophagogastric and core questionnaire correlation ranged from -0.65 to 0.62. The tool showed a significant difference between patients with good physical function and those with impaired physical function. The findings suggest that the Amharic version of EORTC QLQ-OG25 is a valid and reliable tool among patients from Ethiopia with esophagus and gastric cancer. Therefore, we recommend that researchers and clinicians use the core tool together with the specific tool.

Abebe LG ，Wondimagegnehu A ，Kantelhardt EJ ，Addissie A ... -  《Cancer Reports》

Clinical and psychometric validation of a questionnaire module, the EORTC QLQ-OG25, to assess health-related quality of life in patients with cancer of the oesophagus, the oesophago-gastric junction and the stomach.

Lagergren P ，Fayers P ，Conroy T ，Stein HJ ，Sezer O ，Hardwick R ，Hammerlid E ，Bottomley A ，Van Cutsem E ，Blazeby JM ，European Organisation for Research Treatment of Cancer Gastrointestinal and Quality of Life Groups ... -  《EUROPEAN JOURNAL OF CANCER》