Suppression of the notch signaling pathway by γ-secretase inhibitor GSI inhibits human nasopharyngeal carcinoma cell proliferation.

Notch signaling has been suggested to be required for many human cancers. However, the role of Notch signaling in human nasopharyngeal carcinoma cells (NPC) remains unknown. Here, we report that Notch-1, Notch-2, Notch-3 and Notch-4 are all detected in NPC cells. Notch inhibitor, GSI, suppresses the levels of Notch-1, Notch-2 and Notch-4, but not Notch-3. In addition, GSI inhibits NPC cell proliferation by inducing the cell cycle arrest and apoptosis. Furthermore, GSI inhibits the AKT and MEK signaling, without affecting P38 and JNK1/2. Thus, NPC cells may up-regulate Notch signaling to maintain cell proliferation and targeting the Notch signaling pathway may offer a potential alternative strategy for the treatment of NPC.

Chen SM ，Liu JP ，Zhou JX ，Chen C ，Deng YQ ，Wang Y ，Tao ZZ ... -  《-》

Inhibition of gamma-secretase affects proliferation of leukemia and hepatoma cell lines through Notch signaling.

Suwanjunee S ，Wongchana W ，Palaga T 《ANTI-CANCER DRUGS》

Gamma-secretase inhibitors suppress the growth of leukemia and lymphoma cells.

Kogoshi H ，Sato T ，Koyama T ，Nara N ，Tohda S ... -  《ONCOLOGY REPORTS》

Downregulation of Notch pathway by a gamma-secretase inhibitor attenuates AKT/mammalian target of rapamycin signaling and glucose uptake in an ERBB2 transgenic breast cancer model.

Efferson CL ，Winkelmann CT ，Ware C ，Sullivan T ，Giampaoli S ，Tammam J ，Patel S ，Mesiti G ，Reilly JF ，Gibson RE ，Buser C ，Yeatman T ，Coppola D ，Winter C ，Clark EA ，Draetta GF ，Strack PR ，Majumder PK ... -  《-》

Gamma-secretase inhibitors exerts antitumor activity via down-regulation of Notch and Nuclear factor kappa B in human tongue carcinoma cells.

Yao J ，Duan L ，Fan M ，Wu X ... -  《-》