Octreotide lessens peritoneal injury in experimental encapsulated peritoneal sclerosis model.

Encapsulated peritoneal sclerosis is characterized by neoangiogenesis and fibrosis. Octreotide, a somatostatin analogue is a well-known antifibrotic, antiproliferative and anti-angiogenic agent. The aim of the study is to evaluate the effects of octreotide in encapsulated peritoneal sclerosis-induced neoangiogenesis and fibrosis and compare the results with resting. Non-uraemic Wistar-Albino male rats (n = 35) were divided into four groups. Group I, control rats, received 2 mL isotonic saline i.p. daily for 3 weeks. Group II, received daily i.p. 2 mL/200 g injection of chlorhexidine gluconate (0.1%) and ethanol (%15) dissolved in saline for 3 weeks. Group III, chlorhexidine gluconate for 3 weeks plus an additional 3 weeks without any treatment (rest), to a total of 6 weeks. Group IV, chlorhexidine gluconate for 3 weeks plus an additional 3 weeks octreotide, 50 mcg/kg bodyweight s.c., for a total of 6 weeks. Octreotide significantly reversed ultrafiltration capacity of peritoneum with decreasing inflammation, neoangiogenesis and fibrosis compared to the resting group. Octreotide also caused inhibition of dialysate transforming growth factor-β1, vascular endothelial growth factor and monocyte chemotactic protein-1 activity and improved mesothelial cell cytokeratin expression. Peritoneal resting has no beneficial effects on peritoneum. In conclusion, octreotide may have a therapeutic value in peritoneal dialysis patients who suffer from encapsulated peritoneal sclerosis.

Ertilav M ，Hur E ，Bozkurt D ，Sipahi S ，Timur O ，Sarsik B ，Akcicek F ，Duman S ... -  《-》

The effects of mycophenolate mofetil on encapsulated peritoneal sclerosis model in rats.

Hur E ，Bozkurt D ，Timur O ，Bicak S ，Sarsik B ，Akcicek F ，Duman S ... -  《CLINICAL NEPHROLOGY》

A novel angiogenesis inhibitor, sunitinib malate, in encapsulating peritoneal sclerosis.

Bozkurt D ，Sarsik B ，Hur E ，Ertilav M ，Karaca B ，Timur O ，Bicak S ，Akcicek F ，Duman S ... -  《-》

Role of tyrosine kinase inhibition with imatinib in an encapsulating peritoneal sclerosis rat model.

Velioglu A ，Tugtepe H ，Asicioglu E ，Yilmaz N ，Filinte D ，Arikan H ，Koc M ，Tuglular S ，Kaya H ，Ozener C ... -  《-》

TGF-β1-VEGF-A pathway induces neoangiogenesis with peritoneal fibrosis in patients undergoing peritoneal dialysis.

Kariya T ，Nishimura H ，Mizuno M ，Suzuki Y ，Matsukawa Y ，Sakata F ，Maruyama S ，Takei Y ，Ito Y ... -  《-》