Akinetic-rigid and tremor-dominant Parkinson's disease patients show different patterns of FP-CIT single photon emission computed tomography.

To elucidate whether Parkinson's disease subtypes show a different pattern of Iodine-123 fluoropropyl-;carbomethoxy-3 β-(FP-CIT) single photon emission computed tomography (SPECT) binding in accordance with neuropathological findings. We analyzed a database of consecutive patients with FP-CIT scan (n = 190) over a 3-year period and identified 122 patients (50 women, 72 men, mean age 62 ± 11.1 years) with a diagnosis of idiopathic Parkinson's disease. Patient's characteristics and FP-CIT scan results were analyzed and compared for the subgroups tremor-dominant versus akinetic-rigid and equivalent type of Parkinson's disease. The analysis of all Parkinson's disease patients showed a significant difference between the FP-CIT uptake in the subgroups tremor-dominant and akinetic-rigid. After matching these samples for age, disease duration, disease severity (Hoehn & Yahr grade, Unified Parkinson's Disease Rating Scale score), and levodopa-equivalent dose, these findings were balanced between both groups (n = 23/23) without a significant difference (P > 0.05). However, there was a clear, significant association of visually analyzed shapes of the striatum in FP-CIT SPECT and clinical Parkinson's disease subtype. These results confirm neuropathological models for a reduced dopaminergic projection to the dorsal putamen in akinetic-rigid patients as well as the lateral putamen and caudate nucleus in tremor-dominant patients in vivo.

Eggers C ，Kahraman D ，Fink GR ，Schmidt M ，Timmermann L ... -  《-》

[123I]FP-CIT striatal binding in early Parkinson's disease patients with tremor vs. akinetic-rigid onset.

Isaias IU ，Benti R ，Cilia R ，Canesi M ，Marotta G ，Gerundini P ，Pezzoli G ，Antonini A ... -  《NEUROREPORT》

Striatal FP-CIT uptake differs in the subtypes of early Parkinson's disease.

Spiegel J ，Hellwig D ，Samnick S ，Jost W ，Möllers MO ，Fassbender K ，Kirsch CM ，Dillmann U ... -  《JOURNAL OF NEURAL TRANSMISSION》

Differences in nigro-striatal impairment in clinical variants of early Parkinson's disease: evidence from a FP-CIT SPECT study.

Rossi C ，Frosini D ，Volterrani D ，De Feo P ，Unti E ，Nicoletti V ，Kiferle L ，Bonuccelli U ，Ceravolo R ... -  《-》

Different patterns of nigrostriatal degeneration in tremor type versus the akinetic-rigid and mixed types of Parkinson's disease at the early stages: molecular imaging with 123I-FP-CIT SPECT.

Schillaci O ，Chiaravalloti A ，Pierantozzi M ，Di Pietro B ，Koch G ，Bruni C ，Stanzione P ，Stefani A ... -  《-》