Seroprevalence of hepatitis D virus and its risk factors in the west of Iran.

Despite the decreasing trend in hepatitis D virus (HDV) infection worldwide, the importance of this disease cannot be underestimated. The aim of this study was to evaluate patients positive for HBsAg with respect to HDV infection and related factors. Patients with chronic hepatitis B who presented at Hamedan Province Hepatitis Community Center in 2002-2007 were included. A questionnaire covering demographic variables and history of hepatic disease was completed for each patient. Necessary tests were performed and antibodies to HDV were measured using an enzyme-linked immunosorbent assay. Of 81 HBsAg positive patients, 14 (17.3%) contained anti-HDV IgG. Only one of the patients with anti-HDV IgM was positive for HBsAg. Of the anti-HDV IgG positive patients, two (14.3%) were women. Among the women examined in this study, 24 (35.8%) were anti-HDV IgG negative (p = 0.21), and of these, six (42.8%) were HBeAg positive while 17 (25.4%) of the anti-HDV IgG negative women were positive for HBeAg (p = 0.16). The prevalence of chronic hepatitis B among anti-HDV IgG positive and negative patients was 28.6% and 39.2% respectively (p = 0.31). Because of the relatively high rate of hepatitis B virus (HBV) and HDV co-infection in our study subjects, it is vital that healthcare providers and policy makers to recognize the risk factors associated with this HBV and HDV co-infection as well as the reasons for this increased anti-HDV serology in HBV carriers.

Mohammad Alizadeh AH ，Ranjbar M ，Tehrani AS ，Keramat F ，Mamani M ，Rezazadeh M ，Aini P ，Khalilian A ，Majlesi A ，Hajilooi M ... -  《-》

Prevalence and clinical significance of hepatitis D virus co-infection in patients with chronic hepatitis B in Korea.

Hepatitis D virus (HDV) infection can cause severe acute and chronic liver disease in patients infected with hepatitis B virus (HBV). Despite the significant decline in the global HDV infection, it remains a major health concern in some countries. This study aimed to investigate the prevalence and clinical features of HDV co-infection in patients with chronic HBV infection in Korea, where HBV infection is endemic. Nine hundred forty patients [median age, 48 (18-94) years; men, 64.5%] infected chronically with HBV were enrolled consecutively. All patients who were positive for hepatitis B surface antigen (HBsAg) for at least 6 months and were tested for anti-HDV. A portion of the HDV delta antigen was amplified, sequenced, and subjected to molecular and phylogenetic analysis using sera from the patients who were anti-HDV positive. Clinical features and virologic markers were evaluated. Inactive HBsAg carriers, chronic hepatitis B, cirrhosis and hepatocellular carcinoma accounted for 29.5%, 44.7%, 17.9%, and 8.0%, respectively. Only three patients were positive for anti-HDV, corresponding to a 0.32% positive rate. All patients who were positive for anti-HDV were inactive HBsAg carriers. HDV RNA could be amplified by PCR from the sera of two patients. Phylogenetic analysis showed that both carried HDV genotype 1. In conclusion, the prevalence of HDV infection is very low (0.32%) in Korea. All HDVs were genotype 1 and detected in inactive HBsAg carriers. Therefore, HDV co-infection may not have a significant clinical impact in Korean patients with chronic HBV infection.

Kim HS ，Kim SJ ，Park HW ，Shin WG ，Kim KH ，Lee JH ，Kim HY ，Jang MK ... -  《-》

Seroepidemiology of hepatitis B, delta and human immunodeficiency virus infections in Hamadan province, Iran: a population based study.

Amini S ，Mahmoodi MF ，Andalibi S ，Solati AA ... -  《-》

Prevalence of hepatitis D virus infection in hepatitis B surface antigen-positive subjects in Golestan province, northeast Iran.

Roshandel G ，Semnani S ，Abdolahi N ，Besharat S ，Keshtkar AA ，Joshaqani H ，Moradi A ，Kalavi K ，Jabbari A ，Kabir MJ ，Hosseini SA ，Sedaqat SM ，Danesh A ，Roshandel D ，Hedayat-Mofidi SM ... -  《JOURNAL OF MICROBIOLOGY IMMUNOLOGY AND INFECTION》

High prevalence of hepatitis B virus and hepatitis D virus in the western Brazilian Amazon.

Viana S ，Paraná R ，Moreira RC ，Compri AP ，Macedo V ... -  《AMERICAN JOURNAL OF TROPICAL MEDICINE AND HYGIENE》