Angiopoietin-2 inhibits the growth of tongue carcinoma without affecting expression of vascular endothelial growth factor.

Angiopoietin-2 (Ang-2) has been identified as an important factor in tumour angiogenesis through its action in blocking the stabilizing actions of Ang-2 and leading to new tumour vessel growth in the presence of vascular endothelial growth factor (VEGF). In the authors' previous study, over-expression of Ang-2 in Tca8113 tongue tumour cells inhibited growth. The current study aims to clarify the mechanisms of Ang-2-mediated tumour growth inhibition and its role in the regulation of VEGF expression. These studies used tumours derived from Ang-2-transfected Tca8113 cells injected into nude mice. The results showed that Ang-2-transfected tumours displayed aberrant angiogenic vessels with few associated smooth muscle cells. No detectable differences in VEGF expression were observed between Ang-2-transfected and parental tumours. Tumours produced by the Ang-2 transfection also had a higher apoptosis index and lower tumour cell proliferative index than tumours in the control groups. These observations suggest that enhanced expression of Ang-2 has no effect on VEGF expression and results in tumour vessel regression and inhibition of tumour growth.

Chen HH ，Chai L ，Wang SQ ，Shi ZJ ，Wu QL ... -  《-》

The effects of angiopoietin-2 on the growth of tongue carcinoma.

Chen HH ，Shi ZJ ，Wang SQ ，Wu QL ... -  《-》

Tumor-derived vascular endothelial growth factor up-regulates angiopoietin-2 in host endothelium and destabilizes host vasculature, supporting angiogenesis in ovarian cancer.

Zhang L ，Yang N ，Park JW ，Katsaros D ，Fracchioli S ，Cao G ，O'Brien-Jenkins A ，Randall TC ，Rubin SC ，Coukos G ... -  《CANCER RESEARCH》

Angiopoietin-2 is related to tumor angiogenesis in gastric carcinoma: possible in vivo regulation via induction of proteases.

Etoh T ，Inoue H ，Tanaka S ，Barnard GF ，Kitano S ，Mori M ... -  《CANCER RESEARCH》

Inhibiting the growth of malignant melanoma by blocking the expression of vascular endothelial growth factor using an RNA interference approach.

Tao J ，Tu YT ，Huang CZ ，Feng AP ，Wu Q ，Lian YJ ，Zhang LX ，Zhang XP ，Shen GX ... -  《BRITISH JOURNAL OF DERMATOLOGY》