Elevated umbilical cord serum TARC/CCL17 levels predict the development of atopic dermatitis in infancy.

Thymus-and-activation-regulated chemokine (TARC; CCL17) is related to both allergy and pregnancy, but the relationships of maternal and umbilical cord blood CCL17 to atopic dermatitis (AD) development have not yet been examined. Objective Seventy paired full-term and normal vaginal delivery newborns and their mothers were enrolled in this study. To elucidate the pathogenesis and fetomaternal inheritance of AD in infancy, CCL17, IFN-γ-inducible protein 10 kDa (IP-10; CXCL10), soluble HLA-G (sHLA-G), IgE and eosinophil counts were examined using sera from 70 paired umbilical cord and maternal blood samples. Serum CCL17 (r(s) =0.340, P<0.001) and sHLA-G (r(s) =0.600, P<0.001) levels showed high correlations between umbilical cord and maternal blood. Umbilical cord serum levels of CCL17 from neonates destined to develop AD in infancy were higher than in those from neonates who showed no signs of AD during infancy (median 1586.9 vs. 819.6 pg/mL, P<0.001). Serum levels of CCL17 were higher in mothers with AD than in those without AD (median 909.6 vs. 214.1 pg/mL, P<0.001). High umbilical cord serum levels of CCL17 were associated with infantile AD development even in 62 neonates born to mothers without AD (median 1514.4 vs. 740.6 pg/mL, P<0.001) and 38 neonates born to mothers with no allergies (median 1624.2 vs. 740.6 pg/mL, P<0.001). The summary estimates for umbilical cord serum CCL17 in the diagnosis of infantile AD were: sensitivity 85.7% (95% confidence interval: 72.8-98.7), specificity 73.8% (60.5-87.1), positive predictive value 68.6% (53.2-84.0) and negative predictive value 88.6% (78.0-99.1). These findings suggest that the umbilical cord blood CCL17 may be involved in the pathogenesis of infantile AD and in fetomaternal inheritance. Serum levels of CCL17 from umbilical cord blood may be a predictive marker for AD in infancy.

Miyahara H ，Okazaki N ，Nagakura T ，Korematsu S ，Izumi T ... -  《-》

Serum measurement of thymus and activation-regulated chemokine/CCL17 in children with atopic dermatitis: elevated normal levels in infancy and age-specific analysis in atopic dermatitis.

Fujisawa T ，Nagao M ，Hiraguchi Y ，Katsumata H ，Nishimori H ，Iguchi K ，Kato Y ，Higashiura M ，Ogawauchi I ，Tamaki K ... -  《-》

Are age-specific high serum IgE levels associated with worse symptomatology in children with atopic dermatitis?

Hon KL ，Lam MC ，Leung TF ，Wong KY ，Chow CM ，Fok TF ，Ng PC ... -  《INTERNATIONAL JOURNAL OF DERMATOLOGY》

Thymus and activation regulated chemokines in children with atopic dermatitis: Kyushu University Ishigaki Atopic Dermatitis Study (KIDS).

Furusyo N ，Takeoka H ，Toyoda K ，Murata M ，Maeda S ，Ohnishi H ，Fukiwake N ，Uchi H ，Furue M ，Hayashi J ... -  《EUROPEAN JOURNAL OF DERMATOLOGY》

Thymus and activation-regulated chemokine in atopic dermatitis: Serum thymus and activation-regulated chemokine level is closely related with disease activity.

Kakinuma T ，Nakamura K ，Wakugawa M ，Mitsui H ，Tada Y ，Saeki H ，Torii H ，Asahina A ，Onai N ，Matsushima K ，Tamaki K ... -  《JOURNAL OF ALLERGY AND CLINICAL IMMUNOLOGY》