Induced pluripotent stem cells.

Reprogramming of mouse and human somatic cells into induced pluripotent stem (iPS) cells has been possible with retroviral expression of the pluripotency-associated transcription factors Oct4, Sox2, Nanog, and Lin28 as well as Klf4 and c-Myc. iPS cells hold great potential as a model for diseases from the perspective of the individual patient and as an alternative source of pluripotent stem cells for therapeutic applications. In this chapter, we discuss how the use of retroviruses as well as other expression vectors, protein transduction, and small molecules can effectively and efficiently induce pluripotent stem cells from a variety of mouse and human starting somatic cell populations.

Zaehres H ，Kim JB ，Schöler HR 《-》

Using small molecules to improve generation of induced pluripotent stem cells from somatic cells.

Desponts C ，Ding S 《-》

Klf4 interacts directly with Oct4 and Sox2 to promote reprogramming.

Wei Z ，Yang Y ，Zhang P ，Andrianakos R ，Hasegawa K ，Lyu J ，Chen X ，Bai G ，Liu C ，Pera M ，Lu W ... -  《-》

Oct4 and klf4 reprogram dermal papilla cells into induced pluripotent stem cells.

Tsai SY ，Clavel C ，Kim S ，Ang YS ，Grisanti L ，Lee DF ，Kelley K ，Rendl M ... -  《-》

Adenoviral gene delivery can reprogram human fibroblasts to induced pluripotent stem cells.

Zhou W ，Freed CR 《-》